Simultaneous Removal of Endotoxin and Circulating Histones by Heparin-Grafted Chitosan-Cellulose Composite Microspheres for Multitargeted Hemoperfusion in Septic Blood.
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DOI: 10.1021/acs.biomac.5c01085
Abstract: Endotoxin and circulating histones form a pathogenic loop, driving immune dysregulation in sepsis. A multitargeted extracorporeal blood purification combining endotoxin adsorption with histone neutralization may represent a critical therapeutic approach to improve the clinical outcomes… read more here.
Keywords: hemoperfusion; heparin grafted; circulating histones; blood ... See more keywords
Circulating Histones to Detect and Monitor the Progression of Cancer
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DOI: 10.3390/ijms24020942
Abstract: Liquid biopsies have emerged as a minimally invasive cancer detection and monitoring method, which could identify cancer-related alterations in nucleosome or histone levels and modifications in blood, saliva, and urine. Histones, the core component of… read more here.
Keywords: histones detect; progression cancer; circulating histones; detect monitor ... See more keywords