Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty
Sign Up to like & getrecommendations! Published in 2025 at "Aging Clinical and Experimental Research"
DOI: 10.1007/s40520-025-03149-7
Abstract: Aging-related frailty increases the risk of falls, disability, and mortality. Frailty is linked to abnormalities in whole-body metabolism. However, the causal relationship between circulating metabolic traits and frailty remains unclear. This study aims to clarify… read more here.
Keywords: metabolites frailty; mendelian randomization; frailty; study ... See more keywords
Analysis of circulating metabolites to differentiate Parkinson’s disease and essential tremor
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136428
Abstract: Parkinson disease (PD) and essential tremor (ET) are two common adult-onset tremor disorders in which prevalence increases with age. PD is a neurodegenerative condition with progressive disability. In ET, neurodegeneration is not an established etiology.… read more here.
Keywords: essential tremor; circulating metabolites; tremor; disease essential ... See more keywords
Relationship between gut microbiota and circulating metabolites in population-based cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13721-1
Abstract: Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles… read more here.
Keywords: circulating metabolites; microbiota; microbiota circulating; gut microbiota ... See more keywords
Bacillus symbiont drives alterations in intestinal microbiota and circulating metabolites of lepidopteran host.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15934
Abstract: The symbiotic association between bacterial symbionts and insect hosts is a complicated process that is not completely understood. Herein, we used a silkworm model to study the association between symbiotic Bacillus and lepidopteran insect by… read more here.
Keywords: intestinal microbiota; alterations intestinal; bacillus; microbiota ... See more keywords
Circulating metabolites associated with incident myocardial infarction and stroke: A prospective cohort study of 90 438 participants
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15659
Abstract: The relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke… read more here.
Keywords: myocardial infarction; 438 participants; risk; cohort ... See more keywords
Associations of circulating metabolites with cerebral white matter hyperintensities.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15845
Abstract: White matter hyperintensities (WMH) are the most compelling risk factors of stroke, dementia, and early mortality. We aimed to investigate the associations between WMH and circulating metabolites. We studied up to 8190 individuals from the… read more here.
Keywords: associations circulating; white matter; associations wmh; circulating metabolites ... See more keywords
Complex Metabolism of the Novel Neurosteroid, Ganaxolone, in Humans: A Unique Challenge for Metabolites in Safety Testing Assessment
Sign Up to like & getrecommendations! Published in 2023 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.001218
Abstract: The human pharmacokinetics, metabolism, and excretion of [14C]-ganaxolone (GNX) were characterized in healthy male subjects (n = 8) following a single 300-mg (150 μCi) oral dose. GNX exhibited a short half-life of 4 hours in… read more here.
Keywords: metabolism; ganaxolone humans; spectroscopy; chemistry ... See more keywords
Abstract 038: Association of Circulating Metabolites with Incident Heart Failure and its Subtypes in Multi-ethnic Populations
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/cir.151.suppl_1.038
Abstract: Introduction: Metabolic dysregulation is recognized in heart failure (HF). A comprehensive assessment of circulating metabolites, specifically on HF subtypes, in multi-ethnic populations is limited. Hypothesis: We hypothesize that circulating metabolites are significantly associated with the… read more here.
Keywords: circulating metabolites; subtypes multi; ethnic populations; multi ethnic ... See more keywords
Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2025029132
Abstract: Acute myeloid leukemia (AML) is characterized by a low five-year survival rate. Despite having many clinical metrics to assess patient prognosis, there remain opportunities to improve risk stratification. We hypothesized that an underexplored resource to… read more here.
Keywords: acute myeloid; myeloid leukemia; survival; circulating metabolites ... See more keywords
1581-P: Circulating Metabolites Are Associated with Glycemic Measures in South Asians
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-1581-p
Abstract: South Asians are at higher risk for diabetes (DM) than many other racial/ethnic groups. Circulating metabolites are measurable products of metabolic processes that may explain the etiology of elevated risk. We characterized metabolites associated with… read more here.
Keywords: circulating metabolites; south asians; glycemic measures; metabolites associated ... See more keywords
Circulating Metabolites Associate with and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0842
Abstract: Obesity is a major concern for global healthcare systems. Systemic low-grade inflammation in obesity is a major risk factor for insulin resistance. Leptin is an adipokine secreted by the adipose tissue that functions by controlling… read more here.
Keywords: inflammation; leptin; insulin resistance; circulating metabolites ... See more keywords