Model-Based Assessment of the Contribution of Monocytes and Macrophages to the Pharmacokinetics of Monoclonal Antibodies.
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DOI: 10.1007/s11095-022-03177-2
Abstract: PURPOSE We have hypothesized that a high concentration of circulating monocytes and macrophages may contribute to the fast weight-based clearance of monoclonal antibodies (mAbs) in young children. Exploring this hypothesis, this work uses modeling to… read more here.
Keywords: model based; circulating monocytes; monocytes macrophages; based assessment ... See more keywords
Magnitude of viremia, antigenemia and infection of circulating monocytes in children with mild and severe dengue.
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DOI: 10.1016/j.actatropica.2016.12.011
Abstract: Dengue is a major public health problem in tropical regions around the world. Viral and immune host factors determine the clinical courses of the infection. We analyzed the dynamics of viremia (by real-time polymerase chain… read more here.
Keywords: antigenemia; viremia antigenemia; infection; circulating monocytes ... See more keywords
Characteristics of circulating monocytes at baseline and after activation in patients with intracranial aneurysm.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2019.11.003
Abstract: Intracranial aneurysm (IA) is a bulging of blood vessels around the brain that is often asymptomatic but may cause severe complications and death if ruptured. Macrophage-mediated immune responses can contribute to the development of IA.… read more here.
Keywords: intracranial aneurysm; circulating monocytes; cd14 cd16; expression ... See more keywords
CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease
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DOI: 10.1093/cvr/cvx224
Abstract: Aims Circulating monocytes infiltrate the plaque and differentiate into macrophages, contributing to an inflammatory environment which is associated with higher risk of cardiovascular events. Although the pivotal role of circulating monocytes in plaque inflammation has… read more here.
Keywords: risk; arterial wall; inflammation; circulating monocytes ... See more keywords
Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a)
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DOI: 10.1093/eurheartj/ehaa171
Abstract: Abstract Aims Elevated lipoprotein(a) [Lp(a)] is strongly associated with an increased cardiovascular disease (CVD) risk. We previously reported that pro-inflammatory activation of circulating monocytes is a potential mechanism by which Lp(a) mediates CVD. Since potent… read more here.
Keywords: inflammatory activation; patients elevated; treatment; circulating monocytes ... See more keywords
Increased expression of inactive rhomboid protein 2 in circulating monocytes after acute myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Preventive Cardiology"
DOI: 10.1093/eurjpc/zwab061.078
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Deutsche Forschungsgemeinschaft (DFG; Sachbeihilfe HE6092/2) DGK (Deutsche Gesellschaft für Kardiologie) Otto-Hess-Promotionsstipendium Tumor necrosis factor-alpha (TNF-α) levels in the blood increase in the… read more here.
Keywords: expression; circulating monocytes; tnf; following ami ... See more keywords
SAT0004 INCREASED M1 INFLAMMATORY PHENOTYPE OF CIRCULATING MONOCYTES IS ASSOCIATED WITH HISTORY OF CARDIOVASCULAR EVENTS IN RA PATIENTS
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DOI: 10.1136/annrheumdis-2020-eular.6645
Abstract: Background: Cardiovascular (CV) Disease is the main cause of death in Rheumatoid Arthritis (RA). Current tools like Framingham or European SCORE underestimate CV risk in RA patients. Efforts to improve the assessment including RA biomarkers… read more here.
Keywords: circulating monocytes; phenotype circulating; risk; mtorc ... See more keywords
Quantitative and qualitative profiles of circulating monocytes may help identifying tuberculosis infection and disease stages
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DOI: 10.1371/journal.pone.0171358
Abstract: Tuberculosis (TB) is one of the most important cause of morbidity and death among infectious diseases, and continuous efforts are needed to improve diagnostic tools and therapy. Previous published studies showed that the absolute cells… read more here.
Keywords: qualitative profiles; monocytes lymphocytes; infection; ratio monocytes ... See more keywords
In vitro Phenotype Induction of Circulating Monocytes: CD16 and CD163 Analysis
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DOI: 10.2147/jir.s292513
Abstract: Introduction CD14 (monocyte differentiation antigen, LPS binding protein – endotoxin receptor) and CD16 (FcγRIII, Low-affinity receptor for IgG) define three subpopulations of circulating monocytes with different inflammatory and phagocytic capabilities. Contradictory reports exist regarding both… read more here.
Keywords: classical monocytes; circulating monocytes; phenotype; cd163 ... See more keywords
Circulating Monocytes Act as a Common Trigger for the Calcification Paradox of Osteoporosis and Carotid Atherosclerosis via TGFB1-SP1 and TNFSF10-NFKB1 Axis
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DOI: 10.3389/fendo.2022.944751
Abstract: Background Osteoporosis often occurs with carotid atherosclerosis and causes contradictory calcification across tissue in the same patient, which is called the “calcification paradox”. Circulating monocytes may be responsible for this unbalanced ectopic calcification. Here, we… read more here.
Keywords: calcification; circulating monocytes; osteoporosis; atherosclerosis ... See more keywords
Circulating monocytes in acute pancreatitis
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DOI: 10.3389/fimmu.2022.1062849
Abstract: Acute pancreatitis is a common gastrointestinal disease characterized by inflammation of the exocrine pancreas and manifesting itself through acute onset of abdominal pain. It is frequently associated with organ failure, pancreatic necrosis, and death. Mounting… read more here.
Keywords: monocytes acute; circulating monocytes; acute pancreatitis; pancreatitis ... See more keywords