Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Translational Oncology"
DOI: 10.1016/j.tranon.2022.101339
Abstract: Highlights • Current risk prediction models use a variety of factors to identify women at risk of developing breast cancer.• Proteins circulating in blood represent an attractive but currently still underrepresented source of candidates serving… read more here.
Keywords: breast; risk; breast cancer; therapy ... See more keywords
Distinct protein patterns related to postnatal development in small for gestational age preterm infants
Sign Up to like & getrecommendations! Published in 2024 at "Pediatric Research"
DOI: 10.1038/s41390-024-03481-0
Abstract: Preterm infants, especially those born small for gestational age (SGA), are at risk of short-term and long-term health complications. Characterization of changes in circulating proteins postnatally in preterm infants may provide valuable fundamental insights into… read more here.
Keywords: age; gestational age; protein; preterm infants ... See more keywords
Dissecting immune-mediated pathways in rheumatoid arthritis: A multivariate mediation analysis of antibodies and circulating proteins
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-01216-7
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with complex etiologies involving immune responses and circulating proteins. This study investigates the causal relationships between antibody immune responses, plasma circulating proteins, and the development of RA… read more here.
Keywords: multivariate; immune responses; analysis; rheumatoid arthritis ... See more keywords
Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies
Sign Up to like & getrecommendations! Published in 2024 at "Heart"
DOI: 10.1136/heartjnl-2024-324050
Abstract: Background Integration of large proteomics and genetic data in population-based studies can provide insights into discovery of novel biomarkers and potential therapeutic targets for cardiometabolic diseases (CMD). We aimed to synthesise existing evidence on the… read more here.
Keywords: observational mendelian; mendelian randomisation; drug; associations circulating ... See more keywords
Abstract 598: Genetically predicted concentration of circulating proteins and epithelial ovarian cancer risk
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology"
DOI: 10.1158/1538-7445.am2019-598
Abstract: Epithelial ovarian cancer (EOC) is the most common gynecological cancer, and ranks fifth in cancer deaths among women in the United States. Previous studies have identified several circulating proteins biomarkers for EOC risk, such as… read more here.
Keywords: genetically predicted; ovarian cancer; cancer; risk ... See more keywords
Abstract 6366: Pre-diagnostic circulating proteins and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-6366
Abstract: Proteomics has emerged as a potentially important research tool for identifying novel etiological biomarkers of cancer risk. To date, apart from some specific proteins such as insulin-like growth factor -1 and sex hormone binding globulin,… read more here.
Keywords: cancer risk; cancer; breast cancer; circulating proteins ... See more keywords
Abstract 4140333: Maximizing the yield of human genetics-based target discovery from circulating proteins for cardiometabolic diseases
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4140333
Abstract: Background: Circulating proteins are attractive candidate drug targets for cardiometabolic diseases. Identifying promising circulating proteins that have a causal role in disease pathogenesis is challenging and expensive. Mendelian randomization (MR) has emerged as an important… read more here.
Keywords: genetics; human genetics; genetics based; circulating proteins ... See more keywords
Discovery of Schistosoma mekongi circulating proteins and antigens in infected mouse sera
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DOI: 10.1371/journal.pone.0275992
Abstract: Schistosomiasis is a neglected tropical disease caused by an infection of the parasitic flatworms schistosomes. Schistosoma mekongi is a restricted Schistosoma species found near the Mekong River, mainly in southern Laos and northern Cambodia. Because… read more here.
Keywords: schistosoma mekongi; infection; mouse sera; circulating proteins ... See more keywords
Integrative proteogenomic analyses provide novel interpretations of type 1 diabetes risk loci through circulating proteins.
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DOI: 10.2337/db24-0380
Abstract: Circulating proteins may be promising biomarkers or drug targets. Leveraging genome-wide association studies of type 1 diabetes (18,942 cases and 501,638 controls of European ancestry) and circulating protein abundances (10,708 European ancestry individuals), Mendelian randomization… read more here.
Keywords: type diabetes; proteogenomic analyses; provide novel; integrative proteogenomic ... See more keywords
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1394438
Abstract: Background Ankylosing spondylitis (AS) is a complex condition with a significant genetic component. This study explored circulating proteins as potential genetic drug targets or biomarkers to prevent AS, addressing the need for innovative and safe… read more here.
Keywords: targets biomarkers; analysis; drug targets; drug ... See more keywords
Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2025.1529495
Abstract: Background Chronic obstructive pulmonary disease (COPD) is a preventable and treatable condition, yet current therapies do not halt disease progression, highlighting the need for novel treatments. Using an integrated approach combining proteome-wide Mendelian randomization and… read more here.
Keywords: therapeutic targets; proteomic insights; copd; analysis ... See more keywords