Circulating tumour DNA is a promising biomarker for risk stratification of central chondrosarcoma with IDH1/2 and GNAS mutations.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13102
Abstract: Chondrosarcoma (CS) is a rare tumour type and the most common primary malignant bone cancer in adults. The prognosis, currently based on tumour grade, imaging and anatomical location, is not reliable and more objective biomarkers… read more here.
Keywords: chondrosarcoma; ctdna; tumour dna; circulating tumour ... See more keywords
Comparing single‐target and multitarget approaches for postoperative circulating tumour DNA detection in stage II–III colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13294
Abstract: Circulating tumour DNA (ctDNA) detection for postoperative risk stratification in cancer patients has great clinical potential. However, low ctDNA abundances complicates detection. Multitarget (MT) detection strategies have been developed to increase sensitivity. Yet, empirical evidence… read more here.
Keywords: tumour dna; circulating tumour; cancer patients; ctdna detection ... See more keywords
A pilot study for presence of circulating tumour cells in adenoid cystic carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of oral and maxillofacial surgery"
DOI: 10.1016/j.ijom.2020.11.012
Abstract: Adenoid cystic carcinoma (ACC) is a rare salivary gland neoplasm with a poor long-term prognosis due to multiple recurrences and distant metastatic spread. Circulating tumour cells (CTCs) are tumour cells shed from a primary, recurrent,… read more here.
Keywords: tumour cells; presence; cystic carcinoma; circulating tumour ... See more keywords
Exploring sialyl-Tn expression in microfluidic-isolated circulating tumour cells: A novel biomarker and an analytical tool for precision oncology applications.
Sign Up to like & getrecommendations! Published in 2019 at "New biotechnology"
DOI: 10.1016/j.nbt.2018.09.004
Abstract: Circulating tumour cells (CTCs) originating from a primary tumour, lymph nodes and distant metastases hold great potential for liquid biopsies by providing a molecular fingerprint for disease dissemination and its temporal evolution through the course… read more here.
Keywords: tumour cells; precision oncology; circulating tumour; expression ... See more keywords
Circulating tumour cell PD-L1 test for head and neck cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.10.011
Abstract: Immune checkpoint inhibitors have gained traction over the last few years in the treatment of metastatic/recurrent head and neck squamous cell carcinoma (HNSCC) patients. Monoclonal antibodies that block the programmed death 1 (PD-1) receptor and… read more here.
Keywords: tumour cell; cell; circulating tumour; head neck ... See more keywords
Liquid biopsies come of age: towards implementation of circulating tumour DNA
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cancer"
DOI: 10.1038/nrc.2017.7
Abstract: Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated… read more here.
Keywords: liquid biopsies; dna; tumour dna; biopsies come ... See more keywords
Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/nrclinonc.2016.128
Abstract: Despite progressive improvements in the management of patients with locoregionally confined, advanced-stage solid tumours, distant metastasis remains a very common — and usually fatal — mode of failure after attempted curative treatment. Surgery and radiotherapy… read more here.
Keywords: tumour cells; treatment; metastasis; mobilization ... See more keywords
Characterisation of circulating tumour cell phenotypes identifies a partial-EMT sub-population for clinical stratification of pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01350-9
Abstract: BACKGROUND Limited accessibility of the tumour precludes longitudinal characterisation for therapy guidance in pancreatic ductal adenocarcinoma (PDAC). METHODS We utilised dielectrophoresis-field flow fractionation (DEP-FFF) to isolate circulating tumour cells (CTCs) in 272 blood draws from… read more here.
Keywords: characterisation; sub; circulating tumour; cancer ... See more keywords
Dynamic expression of Schlafen 11 (SLFN11) in circulating tumour cells as a liquid biomarker in small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of cancer"
DOI: 10.1038/s41416-022-01811-9
Abstract: INTRODUCTION Small cell lung cancer (SCLC) is an aggressive malignancy with no established biomarkers. Schlafen 11(SLFN11), a DNA/RNA helicase that sensitises cancer cells to DNA-damaging agents, has emerged as a promising predictive biomarker for several… read more here.
Keywords: expression; circulating tumour; biomarker; tumour cells ... See more keywords
Genomic profile of advanced breast cancer in circulating tumour DNA
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22605-2
Abstract: The genomics of advanced breast cancer (ABC) has been described through tumour tissue biopsy sequencing, although these approaches are limited by geographical and temporal heterogeneity. Here we use plasma circulating tumour DNA sequencing to interrogate… read more here.
Keywords: tumour dna; advanced breast; breast cancer; circulating tumour ... See more keywords
Harnessing cell-free DNA: plasma circulating tumour DNA for liquid biopsy in genitourinary cancers
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Urology"
DOI: 10.1038/s41585-020-0297-9
Abstract: In the era of precision oncology, liquid biopsy techniques, especially the use of plasma circulating tumour DNA (ctDNA) analysis, represent a paradigm shift in the use of genomic biomarkers with considerable implications for clinical practice.… read more here.
Keywords: ctdna; dna; tumour dna; liquid biopsy ... See more keywords