Molecularly Engineered Nanobodies for Tunable Pharmacokinetics and Drug Delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00003
Abstract: The use of single-domain antibody fragments, or nanobodies, has gained popularity in recent years as an alternative to traditional monoclonal antibody-based approaches. Relatively little is known, however, about the utility of nanobodies as targeting agents… read more here.
Keywords: molecularly engineered; delivery; nanobodies tunable; engineered nanobodies ... See more keywords
Dipole Orientation Matters: Longer-Circulating Choline Phosphate than Phosphocholine Liposomes for Enhanced Tumor Targeting.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b03160
Abstract: Zwitterionic phosphocholine (PC) liposomes are widely used in drug delivery because of their high biocompatibility and long blood circulation time. We herein report that by flipping the direction of the PC dipole, the resulting choline… read more here.
Keywords: circulation time; phosphocholine liposomes; choline phosphate;
Programmable manipulation of oligonucleotide–albumin interaction for elongated circulation time
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac156
Abstract: Abstract Oligonucleotide (ON) therapeutics are emerging as a new generation of medicine with tremendous potential, but their clinical translation is hampered by inferior stability and short circulation time in the human body. Here, we report… read more here.
Keywords: interaction; manipulation oligonucleotide; circulation time; programmable manipulation ... See more keywords
1245 Cheyne-Stokes Respiration and Circulation Time—A Case to Add to the Mystery
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.1239
Abstract: Lung-to-finger circulation time (LFCT), the time taken for the circulation to reach the fingertips from the lungs, has been shown to correlate inversely with cardiac function (Hosokawa et al. 2015). LFCT can be measured on… read more here.
Keywords: cheyne stokes; time; 1245 cheyne; case ... See more keywords
The effect of zwitterionic surface content on blood circulation time of nanocapsule
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomaterials Applications"
DOI: 10.1177/0885328220935381
Abstract: Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore… read more here.
Keywords: surface; content; circulation time; blood circulation ... See more keywords
A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1128371
Abstract: Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hamster ovary (CHO)… read more here.
Keywords: biodistribution; replacement; lysosomal replacement; replacement enzymes ... See more keywords