Genetic polymorphism of circumsporozoite protein (CSP) in plasmodium malariae isolates from Malaysia.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102519
Abstract: Information about Plasmodium malariae is scanty worldwide due to its "benign" nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P.… read more here.
Keywords: plasmodium malariae; circumsporozoite protein; malariae isolates; isolates malaysia ... See more keywords
Protective efficacy of peptides from Plasmodium vivax circumsporozoite protein
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DOI: 10.1016/j.vaccine.2020.03.063
Abstract: Highlights • Short repeat-region peptides from PvCSP on a VLP protect against malaria.• The AGDR tetramer from PvCSP VK210 can, on a VLP, also protect against malaria.• Full-length PvCSP is much less protective as a… read more here.
Keywords: circumsporozoite protein; peptides plasmodium; protective efficacy; efficacy peptides ... See more keywords
A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
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DOI: 10.1038/s41541-022-00457-1
Abstract: Pre-erythrocytic malaria vaccines that induce high-titer, durable antibody responses can potentially provide protection from infection. Here, we engineered a virus-like particle (VLP)-based vaccine targeting a recently described vulnerable epitope at the N-terminus of the central… read more here.
Keywords: circumsporozoite protein; protection; blood stage; infection ... See more keywords
Polymorphism in the IL-1β promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax.
Sign Up to like & getrecommendations! Published in 2020 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/traa055
Abstract: BACKGROUND It is well established that infection by Plasmodium vivax is a result of host-parasite interactions. In the present study, association with the IL1/IL2 cytokine profiles, anticircumsporozoite protein antibody levels and parasitic loads was evaluated… read more here.
Keywords: circumsporozoite protein; antibody; vivax; plasmodium vivax ... See more keywords
Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China
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DOI: 10.1186/s12936-018-2237-1
Abstract: BackgroundPlasmodium vivax malaria has historically been a major source of disease in Henan, China. In the 1970s, the morbidity of malaria was highest in the country. With support from the government and the efforts of… read more here.
Keywords: isolates henan; vivax isolates; circumsporozoite protein; henan province ... See more keywords
Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias
Sign Up to like & getrecommendations! Published in 2018 at "Malaria Journal"
DOI: 10.1186/s12936-018-2413-3
Abstract: BackgroundPlasmodium malariae is characterized by its long asymptomatic persistence in the human host. The epidemiology of P. malariae is incompletely understood and is hampered by the limited knowledge of genetic polymorphisms. Previous reports from Africa… read more here.
Keywords: plasmodium malariae; circumsporozoite protein; genetic polymorphisms; epidemiology ... See more keywords
Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites
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DOI: 10.1186/s12936-018-2431-1
Abstract: BackgroundRodent malaria parasites where the gene encoding circumsporozoite protein (CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium falciparum or Plasmodium vivax, are used as pre-clinical tools to evaluate CSP vaccines… read more here.
Keywords: circumsporozoite protein; falciparum; falciparum parasites; vivax ... See more keywords
Humoral Immune Responses to P. falciparum Circumsporozoite Protein (Pfcsp) Induced by the RTS, S Vaccine - Current Update.
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DOI: 10.2147/idr.s401247
Abstract: Malaria vaccines targeting the circumsporozoite protein (CSP) of the P. falciparum parasite have been overall relatively promising. RTS, S is a pre-erythrocytic recombinant protein-based malaria vaccine that targets CSP. RTS, S effectiveness shows some limited… read more here.
Keywords: immune responses; humoral immune; falciparum circumsporozoite; circumsporozoite protein ... See more keywords