The role of cold‐inducible RNA binding protein in cell stress response
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30833
Abstract: Cold‐inducible RNA binding protein (CIRP) was discovered after the cells were exposed to a moderate cold shock because its production was induced. Other cellular stresses such as ultraviolet light radiation and hypoxia also could increase… read more here.
Keywords: inducible rna; rna binding; binding protein; cold inducible ... See more keywords
Deficiency in cold‐inducible RNA‐binding protein attenuates acute respiratory distress syndrome induced by intestinal ischemia‐reperfusion
Sign Up to like & getrecommendations! Published in 2017 at "Surgery"
DOI: 10.1016/j.surg.2017.06.004
Abstract: Background. Intestinal ischemia‐reperfusion can occur in shock and mesenteric occlusive diseases, causing significant morbidity and mortality. Aside from local injury, intestinal ischemia‐reperfusion can result in remote organ damage, particularly in the lungs. Cold‐inducible RNA‐binding protein… read more here.
Keywords: acute respiratory; reperfusion; intestinal ischemia; ischemia reperfusion ... See more keywords
Downregulation of CIRP Prone Cells to Oxidative Injury via Regulating Nrf2 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/2416787
Abstract: Cold-inducible RNA-binding protein (CIRP) is a cellular stress-response protein, whose expression can be induced by a variety of stress conditions. Our previous study showed that intracellular CIRP is a protective factor against cellular oxidative stress… read more here.
Keywords: prone cells; signaling pathway; nrf2 signaling; oxidative injury ... See more keywords
Prognostic Value of Plasma Cold-Inducible RNA-Binding Protein in Patients with Acute Coronary Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6119601
Abstract: Background Cold-inducible RNA-binding protein (CIRP) is a proinflammatory cytokine. The Global Registry of Acute Coronary Events (GRACE) risk score has been widely applied in risk stratification in patients with acute coronary syndrome (ACS). We aimed… read more here.
Keywords: plasma cirp; acute coronary; grace; cirp ... See more keywords
Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still's disease.
Sign Up to like & getrecommendations! Published in 2021 at "PloS one"
DOI: 10.1371/journal.pone.0255493
Abstract: BACKGROUND Adult-onset Still's disease (AOSD) is a systemic autoinflammatory disease in which danger-associated molecular patterns (DAMPs)-mediated inflammasome activation seems to be involved in the disease pathogenesis. Cold-inducible RNA-binding protein (CIRP) belongs to a family of… read more here.
Keywords: onset still; adult onset; cirp; inducible rna ... See more keywords
CIRP regulates BEV-induced cell migration in gliomas
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s191249
Abstract: Purpose A better understanding of the underlying molecular mechanisms in treatment failure of bevacizumab (BEV) for malignant glioma would contribute to overcome therapeutic resistance. Methods Here, we used a quantitative proteomic method to identify molecular… read more here.
Keywords: cirp; bev induced; cell; cell migration ... See more keywords
Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.903859
Abstract: Sepsis is characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern (DAMP) that promotes inflammation and induces cell death via apoptosis,… read more here.
Keywords: sepsis; lipid ros; expression; cirp ... See more keywords
Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040395
Abstract: Cold-inducible RNA-binding protein (CIRP) is an intracellular RNA-chaperone and extracellular promoter of inflammation, which is increasingly expressed and released under conditions of hypoxia and cold stress. The functional relevance of CIRP for angiogenesis and regeneration… read more here.
Keywords: angiogenesis regeneration; ischemic tissue; rna; regeneration ischemic ... See more keywords
Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses against Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113397
Abstract: Simple Summary Current immunotherapies based on blockade of immunosuppressive elements provide limited results in liver cancer patients. Here we tested whether combination of this therapy with a vaccine based on the Cold-Inducible RNA Binding Protein… read more here.
Keywords: combination; inducible rna; icpi; cold inducible ... See more keywords