Cost-effectiveness Analysis of Bariatric Surgery for Patients With Nonalcoholic Steatohepatitis Cirrhosis
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DOI: 10.1001/jamanetworkopen.2019.0047
Abstract: Key Points Question Is bariatric surgery cost-effective in patients with nonalcoholic steatohepatitis and compensated cirrhosis? Findings In this simulation model study, laparoscopic sleeve gastrectomy had an incremental cost-effectiveness ratio of $66 119 per quality-adjusted life-year in… read more here.
Keywords: nonalcoholic steatohepatitis; cirrhosis; bariatric surgery; patients nonalcoholic ... See more keywords
Nivolumab in patients with advanced hepatocellular carcinoma and Child‐Pugh class B cirrhosis: Safety and clinical outcomes in a retrospective case series
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DOI: 10.1002/cncr.32206
Abstract: Nivolumab demonstrated durable responses and safety in patients with hepatocellular carcinoma (HCC) with Child‐Pugh class A cirrhosis in the CheckMate 040 trial, with rates of hepatotoxicity that were similar to those of non‐HCC populations. To… read more here.
Keywords: hepatocellular carcinoma; cirrhosis; safety; child pugh ... See more keywords
Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis
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DOI: 10.1002/hep.28765
Abstract: Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality in cirrhosis patients. This provides an opportunity to target the highest‐risk population, yet surveillance rates in the United States and Europe range from 10%… read more here.
Keywords: hepatocellular carcinoma; surveillance; cirrhosis; time ... See more keywords
Rifaximin has no effect on hemodynamics in decompensated cirrhosis: A randomized, double‐blind, placebo‐controlled trial
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DOI: 10.1002/hep.28898
Abstract: Decompensated cirrhosis is characterized by disturbed systemic and splanchnic hemodynamics. Bacterial translocation from the gut is considered the key driver in this process. Intestinal decontamination with rifaximin may improve hemodynamics. This double‐blind, randomized, controlled trial… read more here.
Keywords: placebo; cirrhosis; effect; hemodynamics ... See more keywords
The cirrhotic platelet: Shedding light on an enigma
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DOI: 10.1002/hep.28931
Abstract: When first reading the article by Raparelli et al. in this issue of HEPATOLOGY, we came away with quite different perspectives, as we suspect many readers will depending on their own experience and background in… read more here.
Keywords: cirrhosis; patients cirrhosis; control subjects; platelet ... See more keywords
Peptic ulcer bleeding in patients with cirrhosis: Is it as bad as variceal bleeding?
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DOI: 10.1002/hep.29680
Abstract: Peptic ulcer bleeding (PUB) is among the most common causes of hospitalization worldwide, however, advances in endoscopic and pharmacological therapies have reduced the case fatality rate to 2.1% (1). In contrast, 6-week mortality of acute… read more here.
Keywords: peptic ulcer; ulcer bleeding; cirrhosis; patients cirrhosis ... See more keywords
Advance care planning (ACP) for specialists managing cirrhosis: A focus on patient‐centered care
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DOI: 10.1002/hep.29731
Abstract: Advance care planning (ACP) and goals of care designation (GCD) are being integrated into modern health care. In cirrhosis, uptake and adoption of these practices have been limited with physicians citing many perceived barriers and… read more here.
Keywords: planning acp; cirrhosis; care planning; care ... See more keywords
Patient‐reported outcomes in cirrhosis: A scoping review of the literature
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DOI: 10.1002/hep.29756
Abstract: Patients with cirrhosis seek improvement in their symptoms, functioning, quality of life, and satisfaction with the care they receive. However, these patient‐reported outcomes (PROs) are not routinely measured for clinical care, research, or quality improvement.… read more here.
Keywords: scoping review; patient reported; cirrhosis; patients cirrhosis ... See more keywords
Elbasvir/grazoprevir and sofosbuvir for hepatitis C virus genotype 3 infection with compensated cirrhosis: A randomized trial
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DOI: 10.1002/hep.29852
Abstract: Many direct‐acting antiviral regimens have reduced activity in people with hepatitis C virus (HCV) genotype (GT) 3 infection and cirrhosis. The C‐ISLE study assessed the efficacy and safety of elbasvir/grazoprevir (EBR/GZR) plus sofosbuvir (SOF) with… read more here.
Keywords: ebr gzr; rbv; treatment; cirrhosis ... See more keywords
Antibiotic‐Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant
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DOI: 10.1002/hep.30090
Abstract: The study from Bajaj and colleagues, evaluating gut microbiome–metabonome changes in patients with cirrhosis receiving fecal microbiota transplant (FMT),(1) merits further discussion of its conclusions. In this study, patients with cirrhosis and hepatic encephalopathy (HE)… read more here.
Keywords: fmt; cirrhosis; transplant; patients cirrhosis ... See more keywords
Oxidized Albumin—A Trojan Horse for p38 MAPK‐Mediated Inflammation in Decompensated Cirrhosis
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DOI: 10.1002/hep.30164
Abstract: Overactivation of the innate immune response amplifies hepatic injury and promotes the progression to fibrosis and cirrhosis in many liver diseases. Hepatic and systemic inflammation are triggered in part by factors released from dying hepatocytes,… read more here.
Keywords: albumin trojan; oxidized albumin; trojan horse; horse p38 ... See more keywords