Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nutrition"
DOI: 10.1007/s00394-018-1709-y
Abstract: PurposeEvaluating whether changes in gut microbiota induced by a bifidobacterial strain may have an effect on the hepatic vascular function in portal hypertensive cirrhotic rats.MethodsBile duct ligation (BDL) was performed in rats. A subgroup of… read more here.
Keywords: pseudocatenulatum; hypertensive cirrhotic; portal hypertensive; cirrhotic rats ... See more keywords
Compromised Ileal Mucus Barrier Due to Impaired Epithelial Homeostasis Caused by Notch1 Signaling in Cirrhotic Rats
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06178-6
Abstract: Background In liver cirrhosis, intestinal mucus barrier is rarely studied. Aims This study aimed to investigate whether mucus barrier in ileum is altered in cirrhotic rats and its underlying mechanisms. Methods Thioacetamide was injected to… read more here.
Keywords: ls174t cells; ileal mucus; mucus barrier; cirrhotic rats ... See more keywords
Folic acid ameliorates homocysteine-induced angiogenesis and portosystemic collaterals in cirrhotic rats.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of hepatology"
DOI: 10.1016/j.aohep.2018.12.008
Abstract: INTRODUCTION Liver cirrhosis is characterized by increased intrahepatic resistance, splanchnic vasodilation/angiogenesis, and formation of portosystemic collateral vessels. Collaterals can cause lethal complications such as gastroesophageal variceal hemorrhage. Homocysteine is linked to vascular dysfunction and angiogenesis… read more here.
Keywords: folic acid; angiogenesis; acid ameliorates; mesenteric vascular ... See more keywords
Metformin reduces intrahepatic fibrosis and intrapulmonary shunts in biliary cirrhotic rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2017.05.005
Abstract: Background Liver fibrosis causes portal hypertension which dilates collateral vasculature and enhances extra‐hepatic angiogenesis including intrapulmonary shunts, which subsequently complicates with hepatopulmonary syndrome. Metformin is an anti‐diabetic agent which possesses anti‐inflammation and anti‐angiogenesis properties. This… read more here.
Keywords: intrapulmonary shunts; fibrosis; angiogenesis; intrahepatic fibrosis ... See more keywords
The beneficial effects of curcumin in cirrhotic rats with portal hypertension
Sign Up to like & getrecommendations! Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20171015
Abstract: In liver cirrhosis with portal hypertension, the uneven distribution of vasoactive substances leads to increased intrahepatic vascular resistance and splanchnic vasodilatation. Angiogenesis also induces increased portal inflow and portosystemic collaterals. The collaterals may induce lethal… read more here.
Keywords: angiogenesis; cirrhotic rats; beneficial effects; portal hypertension ... See more keywords
Obeticholic acid ameliorates hepatorenal syndrome in ascitic cirrhotic rats by downregulating the renal 8-iso-PGF2α-activated COX-TXA2 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200452
Abstract: BACKGROUNDS/AIMS This study explores the potential of chronic treatment with the Foresaid X receptor (FXR) agonist obeticholic acid (OCA), which inhibits oxidative stress-related pathogenesis, in ascitic cirrhotic rats with hepatorenal syndrome (HRS) developed 6 weeks… read more here.
Keywords: txa2 pathway; iso; cox txa2; cirrhotic rats ... See more keywords
The firing frequency of spontaneous action potentials and their corresponding evoked exocytosis are increased in chromaffin cells of CCl4‐induced cirrhotic rats with respect to control rats
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14618
Abstract: High catecolamine plasma levels because of sympathetic nervous system over‐activity contribute to cirrhosis progression. The aim of this study was to investigate whether chromaffin cells of the adrenal gland might potentiate the deleterious effect exerted… read more here.
Keywords: chromaffin cells; control; cirrhotic rats; induced cirrhotic ... See more keywords
Nitric oxide mediates effects of acute, not chronic, naltrexone on LPS-induced hepatic encephalopathy in cirrhotic rats.
Sign Up to like & getrecommendations! Published in 2017 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2016-0188
Abstract: Recent studies suggest endogenous opioids and nitric oxide (NO) are involved in the pathophysiology of hepatic encephalopathy (HE). In this study, the interaction between the opioid receptor antagonist and NO was investigated on lipopolysaccharide (LPS)-induced… read more here.
Keywords: lps induced; cirrhotic rats; treatment naltrexone; naltrexone ... See more keywords
Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats
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DOI: 10.1371/journal.pone.0179809
Abstract: Objective Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammation and… read more here.
Keywords: hepatopulmonary syndrome; selective cox; inhibition; inflammation ... See more keywords
Effects of PCSK-9 Inhibition by Alirocumab Treatments on Biliary Cirrhotic Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137378
Abstract: Hyperlipidemia and oxidative stress with elevated oxidized low-density lipoprotein (ox-LDL) exacerbate hepatic inflammation and fibrosis. The plasma level of low-density lipoprotein (LDL) is controlled by proprotein convertase subtilisin/kexin 9 (PCSK9). Alirocumab is a monoclonal antibody… read more here.
Keywords: biliary cirrhotic; cirrhotic rats; oxidative stress; inhibition alirocumab ... See more keywords