Diastereoselective direct amidation/aza-Michael cascade reaction to synthesize cis-1,3-disubstituted isoindolines
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DOI: 10.1016/j.tetlet.2020.152122
Abstract: Abstract A convenient and efficient base-promoted cascade reaction for the synthesis of cis-1,3-disubstituted isoindolines has been reported herein. We discovered that various N-protected imines bearing a Michael acceptor react smoothly with several nitrogenous nucleophiles in… read more here.
Keywords: cis disubstituted; michael; cascade reaction; disubstituted isoindolines ... See more keywords