A Three-Step Process to Facilitate the Enantioselective Assembly of Cis-Fused Octahydrophenanthrenes with a Quaternary Stereocenter.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00451
Abstract: A three-step process for the enantioselective assembly of cis-fused octahydrophenanthrenes with a quaternary stereocenter is reported. This synthetic strategy relies on a regioselective γ-alkylation, a one-pot sequence of asymmetric hydrogenation and oxidation, and an intramolecular… read more here.
Keywords: cis fused; step process; three step; quaternary stereocenter ... See more keywords
Gibbosolide A, a highly functionalized 20-membered macrolide with a terminal cis-fused 2-methylhexahydro-2H-furo[3,2-b]pyran motif: insights into late-stage cyclization of marine macrolides
Sign Up to like & getrecommendations! Published in 2021 at "Organic Chemistry Frontiers"
DOI: 10.1039/d1qo01038g
Abstract: The planar structure and absolute configuration of a sailboat-shaped marine macrolide, featuring twelve carbon stereocenters and a cis-fused ether ring juncture, were unambiguously established by a combined approach of chemistry and spectroscopy. read more here.
Keywords: gibbosolide highly; chemistry; cis fused; membered macrolide ... See more keywords
Ni-catalyzed domino transformation of enopyranoses and 2-iodo phenols/anilines to pyrano cis fused dihydro-benzofurans/indoles.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02028a
Abstract: A Ni-catalyzed direct access to various pyrano cis-fused dihydro benzofurans and indoles from unsaturated enopyranoses and o-iodo phenols/anilines is developed. The domino synthesis of pyrano C2-C1 and C3-C2 cis-fused heteroarynes were achieved both from glycals… read more here.
Keywords: dihydro benzofurans; enopyranoses iodo; cis fused; benzofurans indoles ... See more keywords
Oxidative Kinetic Resolution of cis-Fused Tricyclic 1-Tetralone Derivatives by Guanidine–Bisurea Bifunctional Organocatalyst
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DOI: 10.1055/s-0036-1588151
Abstract: We present an enantioselective synthesis of cis-fused tricyclic 1-tetralones via oxidative kinetic resolution in the presence of cumene hydroperoxide (CHP) and guanidine–bisurea bifunctional organocatalyst. This reaction affords the corresponding α-hydroxylation products together with unreacted tetralones… read more here.
Keywords: bisurea bifunctional; fused tricyclic; guanidine bisurea; kinetic resolution ... See more keywords