A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers
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DOI: 10.1101/2022.05.09.491117
Abstract: All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the… read more here.
Keywords: notch receptor; ligand; cis inhibition; notch ... See more keywords
Mib1 prevents Notch Cis-inhibition to defer differentiation and preserve neuroepithelial integrity during neural delamination
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DOI: 10.1371/journal.pbio.2004162
Abstract: The vertebrate neuroepithelium is composed of elongated progenitors whose reciprocal attachments ensure the continuity of the ventricular wall. As progenitors commit to differentiation, they translocate their nucleus basally and eventually withdraw their apical endfoot from… read more here.
Keywords: defer differentiation; delamination; cis inhibition; integrity ... See more keywords