Cloning of the promoter of rice brown planthopper feeding-inducible gene OsTPS31 and identification of related cis-regulatory elements.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7356
Abstract: BACKGROUND Brown planthopper (BPH; Nilaparvata lugens) is one of the most serious pests of rice in the world. Insect-resistant genetic engineering is a very effective technology to control BPH. The promoters and cis-regulatory elements inducible… read more here.
Keywords: promoter; cis regulatory; rice; regulatory elements ... See more keywords
Dysregulation of Cis-Regulatory Elements in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1007/978-981-13-8958-0_8
Abstract: Cis-regulatory elements (CREs) are DNA sequences in the genome that regulate gene expression through their interaction with transcription factors and the transcription pre-initiation complex. These elements control the expression of genes that define the identity… read more here.
Keywords: dysregulation; dysregulation cis; expression; cis regulatory ... See more keywords
Biased allelic expression in tissues of F1 hybrids between tropical and temperate lotus (Nelumbo nuicfera).
Sign Up to like & getrecommendations! Published in 2021 at "Plant molecular biology"
DOI: 10.1007/s11103-021-01138-8
Abstract: KEY MESSAGE The genome-wide allele-specific expression in F1 hybrids from the cross of tropical and temperate lotus unveils how cis-regulatory divergences affect genes in key pathways related to ecotypic divergence. Genetic variation, particularly cis-regulatory variation,… read more here.
Keywords: tropical temperate; temperate lotus; lotus; expression ... See more keywords
Dynamics of sequestering the limiting p300/CBP, viral cis-regulatory elements, and disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biosciences"
DOI: 10.1007/s12038-020-00051-4
Abstract: Many studies showed that the p300/CBP coactivator is limiting. Here we review three studies that showed how transcription complexes formed on viral cis-regulator elements compete with cellular transcription complexes by sequestrating the p300/CBP coactivator. According… read more here.
Keywords: cis; disease; cis regulatory; viral cis ... See more keywords
Multiplex cis-regulatory analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2019.01.009
Abstract: Recent progress in multiplex cis-regulatory analysis has increased the speed of identifying enhancers and promoters, and enabled efficient incorporation of cis-regulatory information into gene regulatory network models. Three types of barcode reporters have been developed… read more here.
Keywords: multiplex cis; regulatory analysis; cis regulatory;
Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.109
Abstract: RET finger protein (RFP) forms a complex with histone deacetylase 1, resulting in aberrant deacetylation of H3K27ac and dysregulation of cis-regulatory elements. We evaluated the modulatory effects of RFP knockdown on cis-regulatory elements, gene expression,… read more here.
Keywords: glioblastoma; ret finger; cis regulatory; finger protein ... See more keywords
Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110023
Abstract: SUMMARY The global impact of somatic structural variants (SVs) on gene regulation in advanced tumors with complex treatment histories has been mostly uncharacterized. Here, using whole-genome and RNA sequencing from 570 recurrent or metastatic tumors,… read more here.
Keywords: mediated cis; rearrangement mediated; regulatory alterations; expression associations ... See more keywords
Cis-regulatory mutations with driver hallmarks in major cancers
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102144
Abstract: Summary Despite the recent availability of complete genome sequences of tumors from thousands of patients, isolating disease-causing (driver) non-coding mutations from the plethora of somatic variants remains challenging, and only a handful of validated examples… read more here.
Keywords: mutations driver; regulatory mutations; non coding; expression ... See more keywords
Novel cis-regulatory elements as synthetic promoters to drive recombinant protein expression from the Chlamydomonas reinhardtii nuclear genome.
Sign Up to like & getrecommendations! Published in 2022 at "New biotechnology"
DOI: 10.1016/j.nbt.2022.01.001
Abstract: Eukaryotic green microalgae represent a sustainable, photosynthetic biotechnology platform for generating high-value products. The model green alga Chlamydomonas reinhardtii has already been used to generate high value bioproducts such as recombinant proteins and terpenoids. However,… read more here.
Keywords: regulatory elements; expression; cis regulatory; protein expression ... See more keywords
Transcriptional regulation in plants: Using omics data to crack the cis-regulatory code.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in plant biology"
DOI: 10.1016/j.pbi.2021.102058
Abstract: Innovative omics technologies, advanced bioinformatics, and machine learning methods are rapidly becoming integral tools for plant functional genomics, with tremendous recent advances made in this field. In transcriptional regulation, an initial lag in the accumulation… read more here.
Keywords: plant; regulatory code; omics data; cis regulatory ... See more keywords
Developmental effector gene regulation: Multiplexed strategies for functional analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.10.018
Abstract: The staggering complexity of the genome controls for developmental processes is revealed through massively parallel cis-regulatory analysis using new methods of perturbation and readout. The choice of combinations of these new methods is tailored to… read more here.
Keywords: analysis; expression; cis regulatory; effector gene ... See more keywords