Articles with "cis retinal" as a keyword



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Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin.

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Published in 2017 at "Biophysical journal"

DOI: 10.1016/j.bpj.2016.12.005

Abstract: The vertebrate visual photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native ligand. Previously, electrophysiological studies showed that ligand binding of 11-cis-retinal in… read more here.

Keywords: spontaneous release; cis retinal; rhodopsin; release cis ... See more keywords
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Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

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Published in 2020 at "Molecules"

DOI: 10.3390/molecules25214904

Abstract: Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce… read more here.

Keywords: cis retinal; rhodopsin; binding compounds; computational studies ... See more keywords