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Published in 2017 at "Biophysical journal"
DOI: 10.1016/j.bpj.2016.12.005
Abstract: The vertebrate visual photoreceptor rhodopsin (Rho) is a unique G protein-coupled receptor as it utilizes a covalently tethered inverse agonist (11-cis-retinal) as the native ligand. Previously, electrophysiological studies showed that ligand binding of 11-cis-retinal in…
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Keywords:
spontaneous release;
cis retinal;
rhodopsin;
release cis ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25214904
Abstract: Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce…
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Keywords:
cis retinal;
rhodopsin;
binding compounds;
computational studies ... See more keywords