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   Articles with "cisd2" as a keyword



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Cisd2 plays an essential role in corneal epithelial regeneration

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recommendations! Published in 2021 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2021.103654

Abstract: Background Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here we investigate the role of… read more here.

Keywords: ocular surface; cisd2 deficiency; cisd2; corneal epithelial ... See more keywords
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Keeping an eye on Ca2+ signalling to tackle dry eye diseases

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recommendations! Published in 2021 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2021.103741

Abstract: Fig. 1. Loss of CISD2 appears to be an important aspect in the pathogenesis of corneal An early consequence of ageing in humans is a decline in vision. Usually, this is limited to presbyopia starting… read more here.

Keywords: cisd2; corneal epithelium; eye; keeping eye ... See more keywords
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Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging

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recommendations! Published in 2018 at "Aging Cell"

DOI: 10.1111/acel.12705

Abstract: Skeletal muscle has emerged as one of the most important tissues involved in regulating systemic metabolism. The gastrocnemius is a powerful skeletal muscle composed of predominantly glycolytic fast‐twitch fibers that are preferentially lost among old… read more here.

Keywords: skeletal muscle; muscle; cisd2; gastrocnemius ... See more keywords
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Cisd2 is essential to delaying cardiac aging and to maintaining heart functions

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recommendations! Published in 2019 at "PLoS Biology"

DOI: 10.1371/journal.pbio.3000508

Abstract: CDGSH iron-sulfur domain-containing protein 2 (Cisd2) is pivotal to mitochondrial integrity and intracellular Ca2+ homeostasis. In the heart of Cisd2 knockout mice, Cisd2 deficiency causes intercalated disc defects and leads to degeneration of the mitochondria… read more here.

Keywords: heart; cisd2 essential; cardiac aging; cisd2 ... See more keywords
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CISD2 Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells—As a Potential Therapeutic Target for Neurodegenerative Dementia

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recommendations! Published in 2020 at "Frontiers in Aging Neuroscience"

DOI: 10.3389/fnagi.2020.00260

Abstract: Background: Accumulating evidence has demonstrated a significant association between microglia-driven inflammation in the brain and neurodegenerative dementia. We previously showed a significant decline in CISD2 expression in mice models with advanced age. Moreover, we observed… read more here.

Keywords: neurodegenerative dementia; eoc microglial; cisd2; inflammation ... See more keywords
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Downregulation of CISD2 Has Prognostic Value in Non-Small Cell Lung Cancer and Inhibits the Tumorigenesis by Inducing Mitochondrial Dysfunction

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recommendations! Published in 2020 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2020.595524

Abstract: CISD2, a NEET protein that coordinates 2Fe-2S clusters through its CDGSH domain, is critical for normal development and iron homeostasis. CISD2 plays an important role in Fe-S cluster transfer and promotes cancer proliferation. However, its… read more here.

Keywords: cisd2; non small; cancer; small cell ... See more keywords
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Anti-Inflammatory CDGSH Iron-Sulfur Domain 2: A Biomarker of Central Nervous System Insult in Cellular, Animal Models and Patients

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recommendations! Published in 2022 at "Biomedicines"

DOI: 10.3390/biomedicines10040777

Abstract: Spinal cord injury (SCI) promotes brain inflammation; conversely, brain injury promotes spinal neuron loss. There is a need to identify molecular biomarkers and therapeutic targets for central nervous system (CNS) injury. CDGSH iron-sulfur structural domain… read more here.

Keywords: cisd2; central nervous; insult; cdgsh iron ... See more keywords
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Rejuvenation: Turning Back Time by Enhancing CISD2

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232214014

Abstract: The aging human population with age-associated diseases has become a problem worldwide. By 2050, the global population of those who are aged 65 years and older will have tripled. In this context, delaying age-associated diseases and… read more here.

Keywords: age associated; cisd2; hesperetin; associated diseases ... See more keywords