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   Articles with "cisplatin" as a keyword



Comparison of Carboplatin With Cisplatin in Small Cell Lung Cancer in US Veterans

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recommendations! Published in 2022 at "JAMA Network Open"

DOI: 10.1001/jamanetworkopen.2022.37699

Abstract: Key Points Question What is the platinum agent of choice in treating small cell lung cancer (SCLC), cisplatin or carboplatin? Findings In this cohort study of 4408 patients at US Veteran Affairs hospitals, there was… read more here.

Keywords: lung cancer; carboplatin; small cell; carboplatin cisplatin ... See more keywords

Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.

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recommendations! Published in 2022 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2022.0122

Abstract: Importance Induction chemotherapy added to concurrent chemoradiotherapy significantly improves survival for patients with locoregionally advanced nasopharyngeal carcinoma, but the optimal induction regimen remains unclear. Objective To determine whether induction chemotherapy with paclitaxel, cisplatin, and capecitabine… read more here.

Keywords: nasopharyngeal carcinoma; free survival; induction chemotherapy; cisplatin ... See more keywords

Intravenous Magnesium and Cisplatin-Associated Acute Kidney Injury.

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recommendations! Published in 2025 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2025.0756

Abstract: Importance Cisplatin-associated acute kidney injury (CP-AKI) is a frequent complication of cisplatin chemotherapy and is associated with considerable morbidity and mortality. Prophylactic administration of intravenous (IV) magnesium attenuates CP-AKI in animal models; however, its association… read more here.

Keywords: magnesium; cisplatin; associated acute; cisplatin associated ... See more keywords

Predicting Chronic Kidney Disease After Cisplatin Treatment Using Population-Level Data.

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recommendations! Published in 2025 at "JAMA oncology"

DOI: 10.1001/jamaoncol.2025.2590

Abstract: Importance Cisplatin is a widely used treatment for cancer that can permanently damage the kidneys. Treatment modifications and other strategies may prevent chronic kidney disease (CKD) in patients at risk; however, the incidence and predictability… read more here.

Keywords: ckd; egfr; treatment; cisplatin ... See more keywords

p53‐independent Noxa induction by cisplatin is regulated by ATF3/ATF4 in head and neck squamous cell carcinoma cells

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12172

Abstract: The platinum‐based DNA damaging agent cisplatin is used as a standard therapy for locally advanced head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underpinning the cytotoxic effects of this compound are not entirely… read more here.

Keywords: noxa induction; cisplatin; atf3 atf4; cell ... See more keywords

β-TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1.

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recommendations! Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70089

Abstract: Cisplatin is one of the most used anticancer chemotherapy agents; however, over time, patients develop resistance to the treatment, and survival rates drop dramatically. Investigation of tumor cell resistance mechanisms could increase sensitivity and prevent… read more here.

Keywords: dna damage; resistance; cisplatin; trcp ... See more keywords
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Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12760

Abstract: Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive… read more here.

Keywords: hif; hif mitochondria; panax notoginseng; cisplatin ... See more keywords

Inhibiting NFS1 by Targeting Liposomes for Combating Cisplatin‐Resistant Colorectal Cancer

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202519005

Abstract: Cisplatin (CP) resistance causes clinically negative effects on colorectal cancer (CRC) chemotherapy through various mechanisms. Currently, overcoming CP resistance while minimizing systemic toxicity remains an urgent need in CRC treatment. Combination therapy offers an appealing… read more here.

Keywords: colorectal cancer; resistance; cisplatin; crc ... See more keywords

Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma

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recommendations! Published in 2018 at "Advanced Science"

DOI: 10.1002/advs.201700821

Abstract: Abstract Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small‐molecule therapeutics… read more here.

Keywords: cisplatin; osteosarcoma; self stabilized; cddp ... See more keywords

HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202202437

Abstract: Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck, and the prognosis of patients is poor due to chemotherapeutic resistance. Interestingly, patients with HNSCC induced by… read more here.

Keywords: anemia pathway; hpv; serpinb3 expression; hnscc ... See more keywords

MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202203423

Abstract: The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly understood. In the present study, the expression and… read more here.

Keywords: progression cisplatin; cisplatin; myh10; cisplatin resistance ... See more keywords