A low-dose pemetrexed-cisplatin combination regimen induces significant nephrotoxicity in mice compared with pemetrexed or cisplatin alone
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734918
Abstract: Pemetrexed is a cytostatic agent used to treat solid tumors and autoimmune diseases. Pemetrexed exerts its antineoplastic activity by multitargeted disruption of folate-dependent processes that mediate cell replication. Pemetrexed is now combined with cisplatin to… read more here.
Keywords: cisplatin combination; cisplatin alone; physiology; cisplatin ... See more keywords
Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.22.02542
Abstract: PURPOSE Patients with malignant pleural mesothelioma, a rapidly progressing malignancy with a median survival time of 6 to 9 months, have previously responded poorly to chemotherapy. We conducted a phase III trial to determine whether… read more here.
Keywords: time; cisplatin alone; malignant pleural; patients malignant ... See more keywords