Cisplatin binds to the MDM2 RING finger domain and inhibits the ubiquitination activity.
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DOI: 10.1039/d0cc00203h
Abstract: Cisplatin can directly bind to the RING finger domain of MDM2, leading to the zinc-release and protein unfolding. Consequently, cisplatin inhibits the MDM2-mediated ubiquitination, which is the molecular basis of p53 activation. This work provides… read more here.
Keywords: cisplatin binds; finger domain; ring finger; ubiquitination ... See more keywords