Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages
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DOI: 10.1111/cpr.12663
Abstract: Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin… read more here.
Keywords: caspase mediated; mouse macrophages; cisplatin doxorubicin; secondary necrosis ... See more keywords
Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Doxorubicin for 90 Minutes Versus 60 Minutes After Cytoreductive Surgery (CRS). Does the 30-Minute Difference Matter? A Comparative Study in a High Volume Centre
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DOI: 10.21873/anticanres.15563
Abstract: Background/Aim: This study compared the perioperative outcomes after the same combination of hyperthermic intraperitoneal chemotherapy (HIPEC) compounds when administered for 90 min vs. 60 min, while all other therapy variables remained constant. Patients and Methods:… read more here.
Keywords: cisplatin doxorubicin; intraperitoneal chemotherapy; hyperthermic intraperitoneal; cytoreductive surgery ... See more keywords
Cathepsin L promotes chemresistance to neuroblastoma by modulating serglycin
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DOI: 10.3389/fphar.2022.920022
Abstract: Cathepsin L (CTSL), a lysosomal acid cysteine protease, is found to play a critical role in chemosencitivity and tumor progression. However, the potential roles and molecular mechanisms of CTSL in chemoresistance in neuroblastoma (NB) are… read more here.
Keywords: cisplatin doxorubicin; cathepsin; ctsl; expression ... See more keywords
Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids
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DOI: 10.3390/ijms22168362
Abstract: Peptaibols, by disturbing the permeability of phospholipid membranes, can overcome anticancer drug resistance, but their natural hydrophobicity hampers their administration. By a green peptide synthesis protocol, we produced two water-soluble analogs of the peptaibol trichogin… read more here.
Keywords: cancer; peptaibol; activity; cisplatin doxorubicin ... See more keywords