Maltol mitigates cisplatin‐evoked cardiotoxicity via inhibiting the PI3K/Akt signaling pathway in rodents in vivo and in vitro
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DOI: 10.1002/ptr.7405
Abstract: Our current research aims to evaluate the efficiency of a flavor enhancer, maltol (produced by heating ginseng) against cisplatin‐evoked cardiotoxicity by establishing cisplatin‐induced heart injury in vivo and H9C2 rat cardiomyocyte model. The cisplatin‐treated mice… read more here.
Keywords: pi3k akt; evoked cardiotoxicity; cisplatin evoked; maltol ... See more keywords
Pioglitazone, a PPAR&ggr; agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress
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DOI: 10.1097/j.pain.0000000000001448
Abstract: Abstract Painful peripheral neuropathy is a dose-limiting side effect of cisplatin treatment. Using a murine model of cisplatin-induced hyperalgesia, we determined whether a PPAR&ggr; synthetic agonist, pioglitazone, attenuated the development of neuropathic pain and identified… read more here.
Keywords: pioglitazone; drg neurons; cisplatin evoked; ppar ggr ... See more keywords