Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0502
Abstract: Importance Cisplatin-induced ototoxic effects are an important complication that affects testicular cancer survivors as a consequence of treatment. The identification of genetic variants associated with this adverse drug reaction will further our mechanistic understanding of… read more here.
Keywords: induced ototoxic; testicular cancer; ototoxic effects; cisplatin induced ... See more keywords
Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12760
Abstract: Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive… read more here.
Keywords: hif; hif mitochondria; panax notoginseng; cisplatin ... See more keywords
Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss
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DOI: 10.1002/advs.202408777
Abstract: Cisplatin can cause irreversible hearing loss. However, effective approaches to its prevention are not established. In this study, the effect of the traditional Chinese medicine monomer pinoresinol diglucoside (PDG) is evaluated on cisplatin‐induced ototoxicity and… read more here.
Keywords: cisplatin; nuclear receptor; hearing loss; pinoresinol diglucoside ... See more keywords
Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery
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DOI: 10.1002/advs.202502627
Abstract: Cisplatin‐induced ototoxicity remains a clinical dilemma with limited mechanistic understanding and no food and drug administration (FDA)‐approved therapies. Despite emerging roles of small extracellular vesicles (sEV) in drug ototoxicity, their molecular cargo profiles and causal… read more here.
Keywords: cisplatin; induced ototoxicity; mmu mir; cis sev ... See more keywords
Tranilast abrogates cisplatin‐induced testicular and epididymal injuries: An insight into its modulatory impact on apoptosis/proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22817
Abstract: Cisplatin is a chemotherapeutic agent whose therapeutic use is greatly limited by the associated organs' toxicity and particularly, testicular toxicity. Cisplatin‐induced testicular damage reported being mediated through mitochondria‐mediated apoptosis, inflammation, and oxidative stress. Evidence showed… read more here.
Keywords: epididymal injuries; proliferation; induced testicular; cisplatin induced ... See more keywords
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22896
Abstract: The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an… read more here.
Keywords: kidney injury; induced kidney; inhibition; cisplatin induced ... See more keywords
microRNA‐486‐5p is implicated in the cisplatin‐induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23039
Abstract: The proinflammatory property of cisplatin is potentially destructive and contributes to the pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of histone acetyltransferase 1 (HAT1) in acute kidney inflammation are still… read more here.
Keywords: inflammation; cisplatin induced; hat1; tubular epithelial ... See more keywords
N‐acetylcysteine microparticles reduce cisplatin‐induced RSC96 Schwann cell toxicity
Sign Up to like & getrecommendations! Published in 2024 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.1256
Abstract: Cisplatin is known to cause inner ear dysfunction. There is growing evidence that cisplatin‐induced demyelination of spiral or Scarpa's ganglion neurons may play an additional role in drug‐induced ototoxicity alongside afferent neuron injury. As Schwann… read more here.
Keywords: acetylcysteine microparticles; schwann cell; schwann; cisplatin induced ... See more keywords
6‐Shogaol Reduces Renal Macrophage Infiltration by Targeting the STING Pathway to Alleviate Cisplatin Induced Renal Injury
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DOI: 10.1002/ptr.70053
Abstract: Cisplatin is a widely used chemotherapeutic agent, but its dose‐limiting nephrotoxicity remains a major clinical challenge. 6‐Shogaol, a bioactive compound with potent anti‐inflammatory and antioxidant properties, exhibits strong binding affinity for STING—a key mediator in… read more here.
Keywords: cisplatin; macrophage infiltration; injury; shogaol ... See more keywords
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02507-5
Abstract: This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thymidine–enhancer-binding protein homologous protein expression. This effect is indicative of an increase in endoplasmic reticulum (ER)… read more here.
Keywords: cisplatin; induced ototoxicity; cannabinoid; cisplatin induced ... See more keywords
Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01673-8
Abstract: This study investigates the molecular mechanisms of the nephroprotective effect of piceatannol (PIC) against cisplatin-induced nephrotoxicity in rats. PIC (10 mg/kg i.p.) was given for 7 days, starting 2 days before cisplatin single injection (7 mg/kg i.p.). Serum creatinine, blood urea… read more here.
Keywords: hindering inflammatory; cisplatin induced; activation; pic ... See more keywords