Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.0502
Abstract: Importance Cisplatin-induced ototoxic effects are an important complication that affects testicular cancer survivors as a consequence of treatment. The identification of genetic variants associated with this adverse drug reaction will further our mechanistic understanding of… read more here.
Keywords: induced ototoxic; testicular cancer; ototoxic effects; cisplatin induced ... See more keywords
Panax notoginseng saponins ameliorate cisplatin‐induced mitochondrial injury via the HIF‐1α/mitochondria/ROS pathway
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12760
Abstract: Cisplatin is a major antineoplastic drug that is used to treat solid tumors, but its use is restricted by its nephrotoxicity. Such cisplatin‐induced nephrotoxicity (CIN) is believed to occur primarily through mitochondrial damage and reactive… read more here.
Keywords: hif; hif mitochondria; panax notoginseng; cisplatin ... See more keywords
Tranilast abrogates cisplatin‐induced testicular and epididymal injuries: An insight into its modulatory impact on apoptosis/proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22817
Abstract: Cisplatin is a chemotherapeutic agent whose therapeutic use is greatly limited by the associated organs' toxicity and particularly, testicular toxicity. Cisplatin‐induced testicular damage reported being mediated through mitochondria‐mediated apoptosis, inflammation, and oxidative stress. Evidence showed… read more here.
Keywords: epididymal injuries; proliferation; induced testicular; cisplatin induced ... See more keywords
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22896
Abstract: The NOD-like receptor family pyrin domain-containing (NLRP3) inflammasomes is centrally implicated in cisplatin (CP)-induced kidney injury. Autophagy is critical for inhibiting production of NLRP3 protein that effectively reduces the inflammatory response. Ginsenoside Rg3 (SY), an… read more here.
Keywords: kidney injury; induced kidney; inhibition; cisplatin induced ... See more keywords
microRNA‐486‐5p is implicated in the cisplatin‐induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23039
Abstract: The proinflammatory property of cisplatin is potentially destructive and contributes to the pathogenesis of acute kidney injury (AKI). The role and upstream regulatory mechanism of histone acetyltransferase 1 (HAT1) in acute kidney inflammation are still… read more here.
Keywords: inflammation; cisplatin induced; hat1; tubular epithelial ... See more keywords
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02507-5
Abstract: This study investigated whether protein arginine methyltransferase (PRMT) and the cannabinoid system are involved in cisplatin-induced ototoxicity. Cisplatin increased cytosine–cytosine–adenosine–adenosine–thymidine–enhancer-binding protein homologous protein expression. This effect is indicative of an increase in endoplasmic reticulum (ER)… read more here.
Keywords: cisplatin; induced ototoxicity; cannabinoid; cisplatin induced ... See more keywords
Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01673-8
Abstract: This study investigates the molecular mechanisms of the nephroprotective effect of piceatannol (PIC) against cisplatin-induced nephrotoxicity in rats. PIC (10 mg/kg i.p.) was given for 7 days, starting 2 days before cisplatin single injection (7 mg/kg i.p.). Serum creatinine, blood urea… read more here.
Keywords: hindering inflammatory; cisplatin induced; activation; pic ... See more keywords
Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients
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DOI: 10.1007/s00228-018-2552-z
Abstract: PurposeThe ability to predict and detect clinical and subclinical nephrotoxicity early in the course of therapy has the potential to improve long-term outcomes in cancer patients receiving cisplatin chemotherapy. Pharmacokinetic parameters could serve as predictors… read more here.
Keywords: kidney injury; platinum; clusterin; cisplatin induced ... See more keywords
RRx-001 protects against cisplatin-induced toxicities
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DOI: 10.1007/s00432-017-2416-4
Abstract: PurposeRRx-001, a minimally toxic tumor-associated macrophage and neutrophil-repolarizing agent, is under investigation in Phase II clinical trials as a sensitizer/resensitizer to cisplatin and carboplatin. On the basis of anecdotal clinical observations of improved platinum tolerability… read more here.
Keywords: cisplatin; induced toxicities; rrx 001; 001 protects ... See more keywords
TNF-α, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-2981-5
Abstract: Cisplatin is a regularly employed effective chemotherapeutic agent for the treatment of many types of cancer. The main drawback of cisplatin treatment is kidney toxicity which affects 25–35% of treated patients. Many mechanisms are believed… read more here.
Keywords: induced nephrotoxicity; treatment; cisplatin; cisplatin induced ... See more keywords
Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00634-y
Abstract: Neurotoxicity caused by cisplatin is a major obstacle during chemotherapy. Oxidative stress and inflammation are considered the primary mechanism behind neuronal damage which affects the continuing chemotherapy regimen. Agomelatine was recently described as a neuroprotective… read more here.
Keywords: stress inflammation; cisplatin; neurotoxicity; cisplatin induced ... See more keywords