In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors.
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DOI: 10.1101/gr.230219.117
Abstract: Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, its… read more here.
Keywords: secondary malignancies; cisplatin; hepatocellular carcinomas; cisplatin mutational ... See more keywords