Labyrinthine enhancement on 3D black blood MR images of the brain as an imaging biomarker for cisplatin ototoxicity in (lung) cancer patients
Sign Up to like & getrecommendations! Published in 2020 at "Neuroradiology"
DOI: 10.1007/s00234-020-02504-x
Abstract: Purpose Cancer patients treated with platinum-based chemotherapy can present with ototoxicity symptoms. The purpose of this work is to report the imaging features related to cisplatin ototoxicity. Methods Between December 2015 and March 2019, a… read more here.
Keywords: ototoxicity; cisplatin ototoxicity; cancer patients; labyrinthine enhancement ... See more keywords
Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea
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DOI: 10.1038/s41598-019-40425-9
Abstract: Capsaicin, the spicy component of hot chili peppers activates the TRPV1 pain receptors, and causes rapid desensitization. Capsaicin also ameliorates cisplatin-induced nephrotoxicity. Cisplatin, a commonly used anti-neoplastic agent for solid tumors causes significant hearing loss,… read more here.
Keywords: capsaicin; cb2 receptors; cisplatin ototoxicity; stat3 stat1 ... See more keywords
Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy
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DOI: 10.15252/emmm.201606230
Abstract: Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patients is lacking. We found activation… read more here.
Keywords: cisplatin; efficacy; ototoxicity; cisplatin ototoxicity ... See more keywords