Knockdown of replication protein A 3 induces protective autophagy and enhances cisplatin sensitivity in lung adenocarcinoma by inhibiting AKT/mTOR signaling via binding to cyclin‐dependent kinases regulatory subunit 2
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DOI: 10.1002/ddr.21978
Abstract: Replication protein A 3 (RPA3) is a significant component of replication protein A and has been documented to function as an oncogene in several types of cancers. However, the role and underlying mechanism of RPA3… read more here.
Keywords: cell; mtor signaling; akt mtor; cisplatin sensitivity ... See more keywords
Poncirin downregulates ATP‐binding cassette transporters to enhance cisplatin sensitivity in cisplatin‐resistant osteosarcoma cells
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DOI: 10.1002/ptr.6798
Abstract: Poncirin, a flavanone glycoside with bitter taste extracted from dried immature fruit of Poncirus trifoliate, exhibits multiple biological activities including anti‐tumor activity. Our study aimed to determine the effect and potential mechanism of poncirin on… read more here.
Keywords: cisplatin sensitivity; cisplatin resistant; cisplatin; resistance ... See more keywords
Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis
Sign Up to like & getrecommendations! Published in 2018 at "Cell Proliferation"
DOI: 10.1111/cpr.12474
Abstract: We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)‐sensitive and ‐resistant ovarian cancer. read more here.
Keywords: cisplatin sensitivity; enhances cisplatin; roflumilast enhances; ovarian cancer ... See more keywords
Blockade of ClC-3 enhances cisplatin-sensitivity of cholangiocarcinoma cells though inhibiting autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0058
Abstract: Chemotherapy is one of the most important strategies in the treatment of cancer, however, chemo-resistance restricts the effect of chemotherapy. Growing reports suggest that chloride channel-3 (ClC-3) is involved in regulating the sensitivity of multiple… read more here.
Keywords: sensitivity; clc; cisplatin sensitivity; cells though ... See more keywords
MiR-92a Inhibits the Progress of Osteosarcoma Cells and Increases the Cisplatin Sensitivity by Targeting Notch1
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DOI: 10.1155/2018/9870693
Abstract: Background MicroRNAs (miRs) have been implicated in the development and progression of osteosarcoma. Here, we aimed to illustrate the important role of miR-92a on the regulation of OS development which may help to establish a… read more here.
Keywords: cisplatin sensitivity; 92a inhibits; cell; targeting notch1 ... See more keywords
Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours
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DOI: 10.1186/s12885-020-06820-6
Abstract: Background Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathway has been implicated in the regulation… read more here.
Keywords: cisplatin sensitivity; nodal signalling; pluripotency; expression ... See more keywords
Human esophageal fibroblast-derived exosomal miR-21 reduced the cisplatin sensitivity to esophageal carcinoma EC9706 cells
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2021e11156
Abstract: The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts (HEF) or… read more here.
Keywords: cisplatin sensitivity; ec9706; mir; esophageal ... See more keywords
MiR-199a-3p enhances cisplatin sensitivity of cholangiocarcinoma cells by inhibiting mTOR signaling pathway and expression of MDR1
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DOI: 10.18632/oncotarget.16834
Abstract: Several studies have reported reduced miRNA-199a-3p (miR-199a-3p) in different human malignancies, however, little is known about miR-199a-3p in cholangiocarcinoma cells. In this study, we demonstrate the essential role and mechanism of miR-199a-3p in regulating cisplatin… read more here.
Keywords: sensitivity cholangiocarcinoma; cisplatin sensitivity; mir 199a; cholangiocarcinoma ... See more keywords
Silencing RIF1 decreases cell growth, migration and increases cisplatin sensitivity of human cervical cancer cells
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DOI: 10.18632/oncotarget.22315
Abstract: Replication timing regulatory factor 1 (RIF1) plays an important role in DNA replication regulation, stem cell pluripotency and DNA repair pathway. However, little is known about the molecular mechanisms and physiological significance of RIF1 in… read more here.
Keywords: rif1 knockdown; cisplatin sensitivity; cervical cancer; cell growth ... See more keywords
NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma
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DOI: 10.18632/oncotarget.23711
Abstract: Osteosarcoma(OS) remains a major health concern in childhood and adolescence, although cisplatin is one of the gold standard chemotherapeutic drugs in the treatment of OS, chemoresistant to cisplatin is common. Phosphoinositide 3-kinase (PI3K)-Akt-mammalian target of… read more here.
Keywords: bez235; nvp bez235; osteosarcoma; cisplatin sensitivity ... See more keywords
HIF2A overexpression reduces cisplatin sensitivity in cervical cancer by inducing excessive autophagy
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DOI: 10.21037/tcr.2019.11.17
Abstract: Background: Hypoxia-induced autophagy is a crucial factor that induces chemotherapy resistance in tumor cells. As a key regulator facilitating the adaptation of solid tumors to hypoxia, the role of hypoxia-inducible factors (HIFs) in regulating hypoxia-induced… read more here.
Keywords: tumor; cisplatin sensitivity; hif2a; hif2a overexpression ... See more keywords