Cisterna magna arachnoid membrane suturing decreases incidence of pseudomeningocele formation and incisional CSF leakage
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-018-3507-y
Abstract: ObjectiveA pseudomeningocele and an incisional cerebrospinal fluid leak are considered frequent complications following neurosurgical operations. The rate of these complications especially increases following neurosurgical procedures on the posterior cranial fossae. According to some publications, the… read more here.
Keywords: arachnoid membrane; membrane suturing; group; membrane ... See more keywords
Intra-cisterna magna delivery of an AAV vector with the GLUT1 promoter in a pig recapitulates the physiological expression of SLC2A1.
Sign Up to like & getrecommendations! Published in 2020 at "Gene therapy"
DOI: 10.1038/s41434-020-00203-z
Abstract: Glucose transporter 1 deficiency syndrome (GLUT1DS) is caused by haplo-insufficiency of SLC2A1, which encodes GLUT1, resulting in impaired hexose transport into the brain. Previously, we generated a tyrosine-mutant AAV9/3 vector in which SLC2A1 was expressed… read more here.
Keywords: aav; intra cisterna; aav glut1; glut1 ... See more keywords
Standardized Method for Intra-Cisterna Magna Delivery Under Fluoroscopic Guidance in Nonhuman Primates.
Sign Up to like & getrecommendations! Published in 2018 at "Human gene therapy methods"
DOI: 10.1089/hgtb.2018.041
Abstract: Intrathecal delivery of adeno-associated virus vectors and other therapeutics are currently being evaluated for the treatment of central nervous system sequelae of lysosomal storage diseases, motor neuron diseases, and neurodegenerative diseases. As products transition from… read more here.
Keywords: delivery; guidance nonhuman; method; fluoroscopic guidance ... See more keywords
Convection-enhanced delivery of botulinum toxin serotype A into the nonhuman primate cisterna magna and hippocampus.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurosurgery"
DOI: 10.3171/2019.4.jns19744
Abstract: OBJECTIVE Botulinum toxin serotype A (BoNT/A) was reported to raise the seizure threshold when injected into the seizure focus of a kindled rodent model. Delivering BoNT/A to the nonhuman primate (NHP) central nervous system via… read more here.
Keywords: hippocampus; bont; cisterna magna; distribution ... See more keywords