123I‐FP‐CIT SPECT [(123) I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐N‐(3‐fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α‐synuclein Parkinson's disease cohort versus Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27451
Abstract: Background: The p.A53T point mutation in the α‐synuclein gene (SNCA) is a rare but highly relevant cause of autosomal dominant Parkinson's disease (PD). read more here.
Keywords: spect 123; disease; 123i cit; cit spect ... See more keywords
Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123I-FP-CIT SPECT study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04324-5
Abstract: PurposeThe aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123I-FP-CIT SPECT imaging.MethodsThe study groups comprised 56 PD patients… read more here.
Keywords: serotonergic pathways; study; dlb patients; 123i cit ... See more keywords
Dopaminergic imaging separates normal pressure hydrocephalus from its mimics
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DOI: 10.1007/s00415-018-9029-y
Abstract: ObjectiveIdiopathic normal pressure hydrocephalus (iNPH) and iNPH mimics (i.e., Parkinson’s disease, progressive supranuclear palsy or dementia with Lewy bodies) share similar clinical features, and discrimination between both conditions relies on invasive time-consuming investigations. This study… read more here.
Keywords: normal pressure; 123i cit; cit spect; inph mimics ... See more keywords
The value of multimodal imaging with 123I-FP-CIT SPECT in differential diagnosis of dementia with Lewy bodies and Alzheimer's disease dementia
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DOI: 10.1016/j.neurobiolaging.2020.12.009
Abstract: Reduced nigrostriatal uptake on N-(3-fluoropropyl)-2β-carbomethoxy-3β-(4-[123I]iodophenyl) nortropane (123I-FP-CIT) SPECT reflects dopamine dysfunction, while other imaging markers could be complementary when used together. We assessed how well 123I-FP-CIT SPECT differentiates dementia with Lewy bodies (DLBs) from Alzheimer's… read more here.
Keywords: dementia; alzheimer disease; multimodal imaging; 123i cit ... See more keywords
Binding potential changes of SERT in patients with depression are associated with remission: A prospective [¹²³I]β-CIT-SPECT study.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental and clinical psychopharmacology"
DOI: 10.1037/pha0000566
Abstract: The status of remission in patients with major depressive disorder treated with selective serotonin reuptake inhibitors (SSRIs) is mostly evaluated with clinical rating scales. Morphological correlates of the remission status remain a rare event. Addressing… read more here.
Keywords: dat; depression; binding potential; remission ... See more keywords
Optimization of the reconstruction parameters in [123I]FP-CIT SPECT.
Sign Up to like & getrecommendations! Published in 2018 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/aab799
Abstract: The aim of this work was to obtain a set of parameters to be applied in [123I]FP-CIT SPECT reconstruction in order to minimize the error between standardized and true values of the specific uptake ratio… read more here.
Keywords: reconstruction; optimization reconstruction; reconstruction parameters; 123i cit ... See more keywords
REMeDio: a proof-of-concept neuroprotection study for prodromal synucleinopathies.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of neurology"
DOI: 10.1111/ene.14664
Abstract: OBJECTIVE To explore the feasibility of a neuroprotection trial in prodromal synucleinopathy, using idiopathic REM sleep behavior disorder (iRBD) as the target population and 123 I-FP-CIT-SPECT as a biomarker of disease progression. METHODS Consecutive iRBD… read more here.
Keywords: treatment; cit spect; arm; 123 cit ... See more keywords
Quantifying Differences Between Affine and Nonlinear Spatial Normalization of FP-CIT Spect Images
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DOI: 10.1142/s0129065722500198
Abstract: Spatial normalization helps us to compare quantitatively two or more input brain scans. Although using an affine normalization approach preserves the anatomical structures, the neuroimaging field is more common to find works that make use… read more here.
Keywords: nonlinear spatial; affine nonlinear; spatial normalization; cit spect ... See more keywords
Extrastriatal 123I-FP-CIT SPECT impairment in Parkinson’s disease – the PPMI cohort
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DOI: 10.1186/s12883-020-01777-2
Abstract: Neuropathological data and nuclear medicine imaging show extensive serotonergic impairment in Parkinson’s disease (PD). We undertook a case-controlled analysis of 123I-FP-CIT SPECT images to measure extrastriatal serotonergic transporters (SERT) in PD using the Parkinson’s Progression… read more here.
Keywords: cit; impairment parkinson; 123i cit; cit spect ... See more keywords
Determining the Degree of Dopaminergic Denervation Based on the Loss of Nigral Hyperintensity on SMWI in Parkinsonism
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DOI: 10.3174/ajnr.a6960
Abstract: BACKGROUND AND PURPOSE: Nigrostriatal dopaminergic function in patients with Parkinson disease can be assessed using 123I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropan dopamine transporter (123I-FP-CIT) SPECT, and a good correlation has been demonstrated between nigral status on SWI and dopaminergic denervation… read more here.
Keywords: nigral hyperintensity; loss; 123i cit; cit spect ... See more keywords
Progressive Olfactory Impairment and Cardiac Sympathetic Denervation in REM Sleep Behavior Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parkinson's Disease"
DOI: 10.3233/jpd-223201
Abstract: Background: Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Objective: We investigated the use of cardiac [123I]meta-iodo-benzyl-guanidine scintigraphy ([123I]MIBG) and olfactory testing— in… read more here.
Keywords: 123i mibg; subjects pathological; cit spect; pathological 123i ... See more keywords