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   Articles with "cited2" as a keyword



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Ectopic expression of CITED2 prior to reprogramming, promotes and homogenises the conversion of somatic cells into induced pluripotent stem cells

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recommendations! Published in 2017 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2017.07.002

Abstract: ABSTRACT Cited2 plays crucial roles in mouse embryonic stem cells self‐renewal, the initiation of the somatic reprogramming process into induced pluripotent stem cells (iPSC) and the suppression of cell senescence. Here, we investigated the potential… read more here.

Keywords: cited2; cited2 expression; expression; reprogramming process ... See more keywords
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Multivalency enables unidirectional switch-like competition between intrinsically disordered proteins

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2117338119

Abstract: Significance Intrinsically disordered proteins must frequently compete for binding to shared interaction hubs to perform their cellular functions. Here, we describe the mechanism by which two disordered proteins that regulate the transcriptional response to hypoxia… read more here.

Keywords: intrinsically disordered; disordered proteins; switch; hif ... See more keywords
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CITED2 Restrains Proinflammatory Macrophage Activation and Response

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recommendations! Published in 2017 at "Molecular and Cellular Biology"

DOI: 10.1128/mcb.00452-17

Abstract: ABSTRACT Macrophages are strategically distributed in mammalian tissues and play an essential role in priming the immune response. However, macrophages need to constantly strike a balance between activation and inhibition states to avoid a futile… read more here.

Keywords: response; cited2; gene expression; macrophage ... See more keywords
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CITED2 alleviates lipopolysaccharide-induced inflammation and pyroptosis in - human lung fibroblast by inhibition of NF-κB pathway.

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recommendations! Published in 2022 at "Allergologia et immunopathologia"

DOI: 10.15586/aei.v50i4.628

Abstract: BACKGROUND Pneumonia, a severe infectious respiratory disease, is one of the leading causes of mortality and morbidity in children. Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) functions as a transcription cofactor, and plays… read more here.

Keywords: mrc cells; pyroptosis; expression; lung ... See more keywords