Structural and Functional Evidence for Citicoline Binding and Modulation of 20S Proteasome Activity: Novel Insights into its Pro-Proteostatic Effect.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.113977
Abstract: Citicoline or CDP-choline is a drug, made up by a cytidine 5'-diphosphate moiety and choline, which upon adsorption is rapidly hydrolyzed into cytidine 5'-diphosphate and choline, easily bypassing the blood-brain barrier. Once in the brain,… read more here.
Keywords: citicoline; functional evidence; structural functional; 20s proteasome ... See more keywords
Citicoline in acute ischemic stroke: A randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0269224
Abstract: Introduction Two pharmacological possibilities exist for an acute ischemic stroke (AIS): recanalization of the occluded artery and neuroprotection from ischaemic injury, the latter’s efficacy being debatable. We sought to determine whether administration of Citicoline immediately… read more here.
Keywords: citicoline; trial; placebo; acute ischemic ... See more keywords
Citicoline for Supporting Memory in Aging Humans.
Sign Up to like & getrecommendations! Published in 2022 at "Aging and disease"
DOI: 10.14336/ad.2022.0913
Abstract: Citicoline is the generic name of CDP-choline, a natural metabolite present in all living cells. Used in medicine as a drug since the 1980-s, citicoline was recently pronounced a food ingredient. When ingested, citicoline breaks… read more here.
Keywords: supporting memory; citicoline supporting; citicoline; aging humans ... See more keywords
Effect of oral citicoline therapy on retinal nerve fiber layer and ganglion cell-inner plexiform layer in patients with primary open angle glaucoma.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2022.03.17
Abstract: AIM To evaluate the short-term effects of oral citicoline therapy on the retinal nerve fiber layer (RNFL) and the macular ganglion cell-inner plexiform layer (mGCIPL) in patients with primary open angle glaucoma (POAG). METHODS Fifty-four… read more here.
Keywords: glaucoma; layer; citicoline; group ... See more keywords
Citicoline ameliorates arsenic-induced hepatotoxicity and diabetes in mice by overexpression of VAMP2, PPAR-γ, As3MT, and SIRT3.
Sign Up to like & getrecommendations! Published in 2023 at "Pesticide biochemistry and physiology"
DOI: 10.2139/ssrn.4289999
Abstract: The use of arsenic in arsenic-based pesticides has been common in many countries in the past and today. There is considerable evidence linking arsenic exposure to hepatotoxicity and diabetes. Destructive phenomena such as hepatic oxidative… read more here.
Keywords: hepatotoxicity diabetes; citicoline; hepatotoxicity; induced hepatotoxicity ... See more keywords
Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00712
Abstract: Aminoglycoside-induced hair cell (HC) loss is one of the most important causes of hearing loss. After entering the inner ear, aminoglycosides induce the production of high levels of reactive oxygen species (ROS) that subsequently activate… read more here.
Keywords: neomycin induced; citicoline; hcs; hair ... See more keywords
Citicoline Treatment in Acute Ischemic Stroke: A Randomized, Single-Blind TMS Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.915362
Abstract: Background Recent research on animal models of ischemic stroke supports the idea that pharmacological treatment potentially enhancing intrinsic brain plasticity could modulate acute brain damage, with improved functional recovery. One of these new drugs is… read more here.
Keywords: study; citicoline; acute ischemic; treatment ... See more keywords
Citicoline Eye Drops Protect Trabecular Meshwork Cells from Oxidative Stress Injury in a 3D In Vitro Glaucoma Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911375
Abstract: Intraocular pressure (IOP) is considered an important modifiable risk factor for glaucoma, which is known as the second leading cause of blindness worldwide. However, lowering the IOP is not always sufficient to preserve vision due… read more here.
Keywords: vitro; oxidative stress; citicoline; trabecular meshwork ... See more keywords
Citicoline for the Management of Patients with Traumatic Brain Injury in the Acute Phase: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13020369
Abstract: Background: Citicoline or CDP-choline is a neuroprotective/neurorestorative drug used in several countries for the treatment of traumatic brain injury (TBI). Since the publication of the controversial COBRIT, the use of citicoline has been questioned in… read more here.
Keywords: traumatic brain; meta analysis; citicoline; analysis ... See more keywords
Application of Citicoline in Neurological Disorders: A Systematic Review
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12103113
Abstract: Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is… read more here.
Keywords: citicoline; cognitive functions; citicoline neurological; review ... See more keywords
Is Citicoline Effective in Preventing and Slowing Down Dementia?—A Systematic Review and a Meta-Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15020386
Abstract: Background: Cognitive impairment is a staggering personal and societal burden; accordingly, there is a strong interest in potential strategies for its prevention and treatment. Nutritional supplements have been extensively investigated, and citicoline seems to be… read more here.
Keywords: meta analysis; preventing slowing; citicoline; citicoline effective ... See more keywords