The vital role of ATP citrate lyase in chronic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01863-0
Abstract: Chronic or non-communicable diseases are the leading cause of death worldwide; they usually result in long-term illnesses and demand long-term care. Despite advances in molecular therapeutics, specific biomarkers and targets for the treatment of these… read more here.
Keywords: citrate lyase; chronic diseases; atp citrate; role ... See more keywords
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.04.015
Abstract: Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that… read more here.
Keywords: citrate lyase; atp citrate; metabolism; lipid metabolism ... See more keywords
Clerodane diterpenoids from Dodonaea viscosa and their inhibitory effects on ATP citrate lyase.
Sign Up to like & getrecommendations! Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2020.112614
Abstract: Six undescribed clerodane diterpenoids, dodovisins A-F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD… read more here.
Keywords: citrate lyase; atp citrate; clerodane; clerodane diterpenoids ... See more keywords
Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101446
Abstract: Both the accumulation of Amyloid-β (Aβ) in plaques and phosphorylation of Tau protein (p-Tau) in neurofibrillary tangles have been identified as two major symptomatic features of Alzheimer's disease (AD). Despite of critical role of Aβ… read more here.
Keywords: citrate lyase; atp citrate; tau; phosphorylation ... See more keywords
GENETIC TARGET VALIDATION FOR ATP-CITRATE LYASE INHIBITION
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35044-1
Abstract: Background: Bempedoic acid is a novel oral agent that reduces hepatic cholesterol synthesis by inhibiting ATP-citrate lyase (ACL) leading to upregulation of the LDL receptor and a reduction in plasma low-density lipoprotein cholesterol (LDL-C). Although… read more here.
Keywords: citrate lyase; atp citrate; target validation; genetic target ... See more keywords
Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-20141-z
Abstract: Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation… read more here.
Keywords: citrate lyase; deficiency; atp citrate; atherosclerotic plaques ... See more keywords
Stewartiacids A–N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-κB
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/c9ra09542j
Abstract: Fourteen previously undescribed naturally occurring C-23 carboxylated triterpenoids, stewartiacids A–N (1–14), were isolated and characterized from the twigs and leaves of the ornamental and medicinal plant Stewartia sinensis (Chinese Stewartia), a ‘vulnerable’ species endemic to… read more here.
Keywords: citrate lyase; atp citrate; inhibitory effects; carboxylated triterpenoids ... See more keywords
Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1773314
Abstract: Abstract ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Lipids and fatty acids were found to be… read more here.
Keywords: citrate lyase; atp citrate; citrate; pharmacophore based ... See more keywords
ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2067478
Abstract: ABSTRACT Introduction ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and isoprenoid biosynthesis, and it is also involved… read more here.
Keywords: citrate lyase; lyase acly; acly; atp citrate ... See more keywords
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000390
Abstract: Purpose of review ATP-citrate lyase (ACLY) has re-emerged as a drug target for LDL cholesterol (LDL-C) lowering. We review ACLY as a therapeutic strategy, its genetics, its molecular and cellular biology, and also its inhibition.… read more here.
Keywords: citrate lyase; atp citrate; genetics; target ... See more keywords
Earlier Degraded Tapetum1 (EDT1) Encodes an ATP-Citrate Lyase Required for Tapetum Programmed Cell Death1[OPEN]
Sign Up to like & getrecommendations! Published in 2019 at "Plant Physiology"
DOI: 10.1104/pp.19.00202
Abstract: The ATP-citrate lyase, Earlier Degraded Tapetum1 (EDT1), plays a fundamental role in rice pollen development and is involved in cellular metabolism and tapetum programmed cell death. In flowering plants, the tapetum cells in anthers undergo… read more here.
Keywords: citrate lyase; atp citrate; earlier degraded; edt1 ... See more keywords