Low serum level of citrullinated histone H3 in patients with dermatomyositis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24876
Abstract: We aimed at analyzing the serum levels of citrullinated histone H3 (CitH3) in patients with dermatomyositis (DM) and their association with disease activity. read more here.
Keywords: patients dermatomyositis; low serum; citrullinated histone; level citrullinated ... See more keywords
Extracellular vesicles and citrullinated histone H 3 in coronavirus disease 2019 (COVID-19) patients.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1522-4131
Abstract: Objectives Pulmonary thrombus formation is a hallmark of coronavirus disease 2019 (COVID-19). A dysregulated immune response culminating in thromboinflammation has been described, but the pathomechanisms remain unclear. Methods We studied 41 adult COVID-19 patients with… read more here.
Keywords: citrullinated histone; disease 2019; disease; covid ... See more keywords
Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction
Sign Up to like & getrecommendations! Published in 2021 at "Open Heart"
DOI: 10.1136/openhrt-2020-001492
Abstract: Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It is unclear if this is related to formation… read more here.
Keywords: non segment; segment elevation; citrullinated histone; myocardial infarction ... See more keywords
Neutrophil stimulation with citrullinated histone H4 slows down calcium influx and reduces NET formation compared with native histone H4
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0251726
Abstract: Peptidylarginine deiminase 4 (PAD4) catalyzes posttranslational modification of many target proteins through converting protein arginine or mono-methylarginine to citrulline. Neutrophil extracellular trap (NET) formation is the most dramatic manifestation of PAD4-mediated hypercitrullination reaction in neutrophils,… read more here.
Keywords: citrullinated histone; histone; net formation; calcium influx ... See more keywords
Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02957
Abstract: Sepsis results in millions of deaths every year, with acute lung injury (ALI) being one of the leading causes of mortality in septic patients. As neutrophil extracellular traps (NETs) are abundant in sepsis, neutralizing components… read more here.
Keywords: cith3; citrullinated histone; histone therapeutic; therapeutic target ... See more keywords
Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.761345
Abstract: Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection that often results in acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). An emerging mechanism of sepsis-induced ARDS involves neutrophils/macrophages undergoing cell… read more here.
Keywords: sepsis; lung injury; sepsis induced; activating caspase ... See more keywords
Quantification of Citrullinated Histone H3 Bound DNA for Detection of Neutrophil Extracellular Traps
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113424
Abstract: Simple Summary Neutrophil extracellular traps (NETs) are extracellular web-like structures comprised of proteins and DNA that have been associated with the development of cancer. Citrullination of histone H3 has been implicated in the formation of… read more here.
Keywords: neutrophil extracellular; dna; citrullinated histone; formation ... See more keywords