Cyclic Citrullinated Peptide Aptamer Treatment Attenuates Collagen-Induced Arthritis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00144
Abstract: We describe the study of a novel aptamer-based candidate for treatment of seropositive rheumatoid arthritis. The candidate is a nanoparticle-formulated cyclic citrullinated peptide aptamer, which targets autoantibodies and/or the immune reactions leading to antibody production.… read more here.
Keywords: aptamer; peptide aptamer; citrullinated peptide; treatment ... See more keywords
A retrospective analysis of the relationship between anti-cyclic citrullinated peptide antibody and the effectiveness of abatacept in rheumatoid arthritis patients
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DOI: 10.1038/s41598-020-76842-4
Abstract: This study aimed to evaluate the effectiveness of abatacept (ABA) by anti-cyclic citrullinated peptide (ACPA) status on disease activity as well as radiographic progression in patients with rheumatoid arthritis (RA) in clinical settings. A retrospective… read more here.
Keywords: citrullinated peptide; anti cyclic; effectiveness abatacept; acpa positive ... See more keywords
OP0118 DISCRETE PATTERNS OF CITRULLINATED PEPTIDE AUTOANTIBODY REACTIVITIES EMERGE DURING PROGRESSION FROM PRE-DISEASE STATE TO DIAGNOSIS OF RHEUMATOID ARTHRITIS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.3399
Abstract: Background Rheumatoid Arthritis (RA) patients with established disease can have autoantibodies reactive to a broad array of citrullinated antigens. Autoantibodies reactive against several citrullinated proteins can develop 10-15 years before the clinical onset of disease.… read more here.
Keywords: citrullinated peptide; diagnosis; time; shareholder johnson ... See more keywords
Antibodies to synthetic citrullinated peptide epitope correlate with disease activity and flares in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0232010
Abstract: Rheumatoid arthritis (RA), caused by the abnormal recognition of human joint cells by autoimmune antibodies, remains the world’s most prevalent autoimmune disease, with over five million people affected and as much as 4% of the… read more here.
Keywords: disease activity; citrullinated peptide; rheumatoid arthritis; disease ... See more keywords
Corrigendum: Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.710831
Abstract: [This corrects the article DOI: 10.3389/fimmu.2020.578848.]. read more here.
Keywords: citrullinated peptide; adult onset; onset anti; corrigendum adult ... See more keywords
PAD4 Immunization Triggers Anti-Citrullinated Peptide Antibodies in Normal Mice: Analysis With Peptide Arrays
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.840035
Abstract: The critical immunological event in rheumatoid arthritis (RA) is the production of antibodies to citrullinated proteins (ACPAs), ie proteins on which arginines have been transformed into citrullines by peptidyl arginine deiminases (PAD). In C3H mice,… read more here.
Keywords: immunization; citrullinated peptide; anti citrullinated; mice ... See more keywords
Association of Interleukin-10 Genotypes and Anticyclic Citrullinated Peptide Antibodies with Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Medical Journal of the Islamic Republic of Iran"
DOI: 10.47176/mjiri.36.95
Abstract: Background: According to recent evidence, there is an association between some genetic factors and rheumatoid arthritis (RA). The aim of this study was to determine whether genetic variations in the interleukin 10 (IL10) and anti-cyclic… read more here.
Keywords: anti ccp; association interleukin; rheumatoid arthritis; citrullinated peptide ... See more keywords