Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93008-y
Abstract: Periodontal disease (PD) can be an important precipitating factor in the production of citrullinated proteins. Its importance is emphasized, but it is not the only way to produce citrullinated proteins. The aim of the current… read more here.
Keywords: periodontal disease; citrullinated proteins; disease; citrullinated protein ... See more keywords
Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac173
Abstract: Abstract Citrullination, the post-translational modification of arginine residues, is catalyzed by the four catalytically active peptidylarginine deiminase (PAD or PADI) isozymes and alters charge to affect target protein structure and function. PADs were initially characterized… read more here.
Keywords: citrullinated proteins; female reproductive; associated diseases; physiology ... See more keywords
Hypoxia induces production of citrullinated proteins in human fibroblast‐like synoviocytes through regulating HIF1α
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12654
Abstract: Hypoxia is a prominent microenvironment feature in a range of disorders including cancer, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel disease (IBD), infection and obesity. Hypoxia promotes biological functions of fibroblast‐like synoviocytes via regulating hypoxia‐inducible factor… read more here.
Keywords: fibroblast like; production; like synoviocytes; citrullinated proteins ... See more keywords
Characterization of Monoclonal Antibodies Recognizing Citrulline-Modified Residues
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.849779
Abstract: Background Citrullination is a post-translational protein modification linked to the occurrence and development of a variety of diseases. The detection of citrullinated proteins is predominately based on antibody detection although currently available reagents demonstrate detection… read more here.
Keywords: 22f1 30g2; detection; characterization monoclonal; citrulline ... See more keywords
Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1084283
Abstract: Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients. Apart from their critical role in homeostasis and thrombosis, platelets have a significant contribution to inflammation… read more here.
Keywords: human platelets; citrullinated proteins; derived citrullinated; proteins microparticles ... See more keywords
Molecular Dynamics Study of Citrullinated Proteins Associated with the Development of Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Proteomes"
DOI: 10.3390/proteomes10010008
Abstract: Biological activity regulation by protein post-translational modification (PTM) is critical for cell function, development, differentiation, and survival. Dysregulation of PTM proteins is present in various pathological conditions, including rheumatoid arthritis (RA). RA is a systemic… read more here.
Keywords: citrullinated proteins; dynamics study; development; molecular dynamics ... See more keywords
Inhibitory effects of ubiquitination of synoviolin by PADI4.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.7764
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory articular disease that is characterized by synovial hyperplasia. A number of signaling pathways are associated with the development and induced symptoms of RA. Notably, patients with RA have… read more here.
Keywords: inhibitory effects; padi4; citrullination; citrullinated proteins ... See more keywords