Recent advances in characterization of citrullination and its implication in human disease research: From method development to network integration.
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202200286
Abstract: Post-translational modifications (PTM) of proteins increase the functional diversity of the proteome and have been implicated in the pathogenesis of numerous diseases. The most widely understood modifications include phosphorylation, methylation, acetylation, O-linked/N-linked glycosylation, and ubiquitination,… read more here.
Keywords: citrullination; disease; development; integration ... See more keywords
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection
Sign Up to like & getrecommendations! Published in 2019 at "Amino Acids"
DOI: 10.1007/s00726-019-02737-y
Abstract: The importance of l-arginine (Arg) and relatives, including l-homoarginine (hArg) and asymmetric dimethylarginine (ADMA), in humans infected with Helicobacter pylori (Hp) is little understood. ADMA is produced by asymmetric dimethylation of the guanidine group of… read more here.
Keywords: citrullination; arg; dimethylation; infection ... See more keywords
Citrullination of adenosine deaminase impairs its binding to dipeptidyl peptidase IV.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106820
Abstract: The presence of citrullinated adenosine deaminase (ADA) was reported in the synovial fluids of rheumatoid arthritis individuals. This work reports the effects of ADA citrullination on the formation/stabilization of ADA complex with dipeptidyl peptidase IV… read more here.
Keywords: dipeptidyl peptidase; ada; citrullination; adenosine deaminase ... See more keywords
Peptidyl arginine deiminases: detection and functional analysis of protein citrullination.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.01.024
Abstract: Citrullination is a post-translational modification of arginine that is catalyzed by the protein arginine deiminases (PADs). Abnormal citrullination is observed in many autoimmune diseases and cancers. Anti-citrullinated protein antibodies (ACPA) are hallmarks of RA and… read more here.
Keywords: peptidyl arginine; arginine deiminases; citrullination; protein citrullination ... See more keywords
12-Plex DiLeu Isobaric Labeling Enabled High-Throughput Investigation of Citrullination Alterations in the DNA Damage Response.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04073
Abstract: Protein citrullination is a key post-translational modification (PTM) that leads to the loss of positive charge on arginine and consequent protein structural and functional changes. Though it has been indicated to play critical roles in… read more here.
Keywords: dna damage; high throughput; citrullination; citrullination alterations ... See more keywords
Enabling Global Analysis of Protein Citrullination via Biotin Thiol Tag-Assisted Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03844
Abstract: Citrullination is a key post-translational modification (PTM) that affects protein structures and functions. Although it has been linked to various biological processes and disease pathogenesis, the underlying mechanism remains poorly understood due to a lack… read more here.
Keywords: citrullination; citrullination via; mass spectrometry; thiol tag ... See more keywords
Differential Protein Citrullination in Human ER– and ER+ Tumor and Adjacent Healthy Breast Tissue
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00551
Abstract: Post-translational modification of arginine to citrulline is catalyzed by members of the peptidylarginine deiminase (PAD) family. Dysregulation of this catalysis is a significant driver of the pathogenesis of numerous inflammatory diseases, including cancer. However, dysregulation… read more here.
Keywords: citrullination; breast; tumor adjacent; adjacent healthy ... See more keywords
Elucidating Citrullination by Mass Spectrometry and its role in Disease Pathogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.0c00474
Abstract: This review focus on discussing key mechanisms in disease pathogenesis mediated by the protein post-translational modification, citrullination. These processes are discussed in depth in the context of complex diseases such as, rheumatoid arthritis, cancer, central… read more here.
Keywords: role; citrullination; mass spectrometry; disease pathogenesis ... See more keywords
Citrullination of Amyloid-β Peptides in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00474
Abstract: Protein citrullination (deimination of arginine residue) is a well-known biomarker of inflammation. Elevated protein citrullination has been shown to colocalize with extracellular amyloid plaques in postmortem AD patient brains. Amyloid-β (Aβ) peptides which aggregate and… read more here.
Keywords: amyloid peptides; alzheimer disease; citrullination amyloid; citrullination ... See more keywords
Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33385-z
Abstract: Neutrophils are critical for the defense against pathogens, in part through the extrusion of extracellular DNA traps, phagocytosis, and the production of reactive oxygen species. Neutrophils may also play an important role in the pathogenesis… read more here.
Keywords: citrullination; pad4; oxidative burst; activation ... See more keywords
Extracellular vesicle signatures and protein citrullination are modified in shore crabs (Carcinus maenas) infected with Hematodinium sp
Sign Up to like & getrecommendations! Published in 2023 at "Virulence"
DOI: 10.1080/21505594.2023.2180932
Abstract: ABSTRACT Epizootiologists recurrently encounter symbionts and pathobionts in the haemolymph (blood equivalent) of shellfish. One such group is the dinoflagellate genus Hematodinium, which contains several species that cause debilitating disease in decapod crustaceans. The shore… read more here.
Keywords: carcinus maenas; citrullination; extracellular vesicle; hematodinium ... See more keywords