The impact of L‐citrulline supplementation on glucose homeostasis, lipid profile, and some inflammatory factors in overweight and obese patients with type 2 diabetes: A double‐blind randomized placebo‐controlled trial
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.6997
Abstract: This study investigated the impact of L‐citrulline on glucose homeostasis, lipid profile, and inflammatory factors in overweight and obese patients with type 2 diabetes (T2D). In total, 54 participants with T2D were assigned to L‐citrulline… read more here.
Keywords: lipid profile; glucose homeostasis; overweight obese; obese patients ... See more keywords
Impact of l‐citrulline on nitric oxide signaling and arginase activity in hypoxic human pulmonary artery endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12221
Abstract: Abstract Impaired nitric oxide (NO) signaling contributes to the development of pulmonary hypertension (PH). The l‐arginine precursor, l‐citrulline, improves NO signaling and has therapeutic potential in PH. However, there is evidence that l‐citrulline might increase… read more here.
Keywords: arginase activity; hypoxic; nitric oxide; citrulline ... See more keywords
Amino Acid Nutrition and Reproductive Performance in Ruminants.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-54462-1_4
Abstract: Amino acids (AAs) are essential for the survival, growth and development of ruminant conceptuses. Most of the dietary AAs (including L-arginine, L-lysine, L-methionine and L-glutamine) are extensively catabolized by the ruminal microbes of ruminants to… read more here.
Keywords: amino acid; ruminal microbes; acid nutrition; nutrition ... See more keywords
Impact of the route of nutrition on gut mucosa in ventilated adults with shock: an ancillary of the NUTRIREA-2 trial
Sign Up to like & getrecommendations! Published in 2019 at "Intensive Care Medicine"
DOI: 10.1007/s00134-019-05649-3
Abstract: PurposeThe effects of the route of nutrition on the gut mucosa of patients with shock are unclear. Plasma citrulline concentration is a marker of enterocyte mass, and plasma intestinal fatty acid binding protein (I-FABP) concentration… read more here.
Keywords: group; nutrition; concentration; citrulline ... See more keywords
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by NG-hydroxy-l-arginine, Nω,Nω-dimethyl-l-citrulline and Nω,Nω-dimethyl-Nδ-hydroxy-l-citrulline: results and overview
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2684-6
Abstract: Asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are endogenous inhibitors of nitric oxide (NO) synthase. SDMA is excreted in the urine without major metabolization. About 10% of daily produced ADMA are excreted unchanged in the… read more here.
Keywords: dimethylarginine; dimethyl; ddah activity; citrulline ... See more keywords
Gut Dysbiosis Increases Gut Barrier Damage during Anti-Leukemia Chemotherapy: Implications for Acute Graft-Versus-Host Disease
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.433
Abstract: We recently reported an association between low pre-conditioning serum citrulline, reflecting unresolved gut barrier injury from prior chemotherapy, and higher incidence of grade II-IV acute graft-versus-host disease (aGVHD). Citrulline is an amino acid exclusively synthesized… read more here.
Keywords: chemotherapy; citrulline; acute graft; barrier damage ... See more keywords
Oral administration of l-citrulline alters the vascular delivery of substances to rat skeletal muscles
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101149
Abstract: Vascular endothelial function deteriorates with age and disease, and the production of vasodilator factors like nitric oxide (NO) decreases. The free amino acid l-citrulline increases vasodilation and blood flow through increased NO production. We examined… read more here.
Keywords: administration; citrulline administration; vascular delivery; skeletal muscles ... See more keywords
Dietary citrulline does not modify rat colon tumor response to chemotherapy, but failed to improve nutritional status.
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DOI: 10.1016/j.clnu.2021.05.035
Abstract: During cancer therapy many patients experience significant malnutrition, leading to decreased tolerance to chemotherapy and decreased survival. Dietary citrulline supplementation improves nutritional status in situations such as short bowel syndrome and aging, and is of… read more here.
Keywords: chemotherapy; response; dietary citrulline; nutritional status ... See more keywords
Arginine Biosynthesis by a Bacterial Symbiont Enables Nitric Oxide Production and Facilitates Larval Settlement in the Marine-Sponge Host
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DOI: 10.1016/j.cub.2020.10.051
Abstract: Larval settlement and metamorphosis are regulated by nitric oxide (NO) signaling in a wide diversity of marine invertebrates.1-10 It is thus surprising that, in most invertebrates, the substrate for NO synthesis-arginine-cannot be biosynthesized but instead… read more here.
Keywords: sponge; marine; settlement; arginine ... See more keywords
Effects of exogenous application of citrulline on prolonged water stress damages in hyssop (Hyssopus officinalis L.): Antioxidant activity, biochemical indices, and essential oils profile.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.127433
Abstract: This study examined the effects of exogenous citrulline (control, 1 and 2 mM) and water availability (100%, 50% and 25% WA) on antioxidant attributes and essential oil constituents of Hyssopus officinalis L. in two successive harvests.… read more here.
Keywords: water stress; water; effects exogenous; citrulline ... See more keywords
l-Citrulline improves cerebral blood flow in migraine model rats
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DOI: 10.1016/j.jff.2017.09.054
Abstract: We have previously reported that intravenous injection of l-citrulline, an α-amino acid isolated from watermelon juice, prevented the decrease in cerebral blood flow (CBF) during cortical spreading depression (CSD) in rats, a widely accepted animal… read more here.
Keywords: blood flow; citrulline; cerebral blood; migraine ... See more keywords