The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress
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DOI: 10.3390/nu14040745
Abstract: The present study investigates whether hesperetin, a citrus flavonoid, can encounter advanced glycation end-product (AGE)-induced Alzheimer’s disease-like pathophysiological changes with the underlying mechanisms. SH-SY5Y cells pretreated with hesperetin before stimulation with AGEs (200 μg/mL) were… read more here.
Keywords: endoplasmic reticulum; reticulum stress; hesperetin; citrus flavonoid ... See more keywords
Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases
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DOI: 10.3390/nu14112228
Abstract: Neurodegenerative disorders affect more than fifty million Americans each year and represent serious health threats as the population ages. Neuroinflammation and oxidative stress are critical in the onset, progression, and pathogenesis of neurodegenerative diseases such… read more here.
Keywords: flavonoid hesperetin; neuroprotective effects; hesperetin; citrus flavonoid ... See more keywords