p27 transcriptionally coregulates cJun to drive programs of tumor progression
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817415116
Abstract: Significance PI3K is activated in over 60% of human cancers, mediating C-terminal p27 phosphorylation. This work reveals cooperation between PI3K and cJun pathways: p27 phosphorylation by PI3K-activated kinases stimulates p27/cJun corecruitment to chromatin and activation… read more here.
Keywords: tumor progression; p27 phosphorylation; p27 cjun; drive ... See more keywords
CD44v6+ Hepatocellular Carcinoma Cells Maintain Stemness Properties through Met/cJun/Nanog Signaling
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DOI: 10.1155/2022/5853707
Abstract: Cancer stem cells (CSCs) are characterized by their self-renewal and differentiation abilities. CD44v6 is a novel CSC marker that can activate various signaling pathways. Here, we hypothesized that the HGF/Met signaling pathway promotes stemness properties… read more here.
Keywords: hcc cells; cjun; site; cd44v6 ... See more keywords
Abstract 1429: C-terminal phosphorylation of p27 promotes cell cycle dependent changes through transcriptional coregulation of cJun and STAT3
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1429
Abstract: p27 is a cyclin dependent kinase (CDK) inhibitor that binds cyclin-CDKs to arrest cell cycle. p27 undergoes PI3K/AKT-mediated C-terminal phosphorylation that alters its protein-protein interactions and function. Our prior work showed C-terminally phosphorylated p27 (p27pT157pT198)… read more here.
Keywords: cjun; p27; phosphorylation; cell cycle ... See more keywords