Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144005
Abstract: Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well… read more here.
Keywords: ck1; physiological functions; stress induced; structure regulation ... See more keywords
The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00891
Abstract: The serine/threonine protein kinase casein kinase 1α (CK1α) functions as a negative regulator of Wnt signaling, phosphorylating β-catenin at serine 45 (P-S45) to initiate its eventual ubiquitin-mediated degradation. We previously showed that the repurposed, FDA-approved… read more here.
Keywords: ck1; wnt; efficiency kcat; pyrvinium enhances ... See more keywords
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01180
Abstract: Specific inhibition of a single kinase isoform is a challenging task due to the highly conserved nature of ATP-binding sites. Casein kinase 1 (CK1) δ and ε share 97% sequence identity in their catalytic domains.… read more here.
Keywords: isoform selective; casein kinase; ck1; structure ... See more keywords
FRQ-CK1 Interaction Underlies Temperature Compensation of the Neurospora Circadian Clock
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.01425-21
Abstract: Temperature compensation allows clocks to adapt to all seasons by having a relatively constant period length at different physiological temperatures, but the mechanism of temperature compensation is unclear. Stability of clock proteins was previously proposed… read more here.
Keywords: ck1; interaction; temperature compensation; clock ... See more keywords
Casein Kinase 1 Alpha 1 is Involved in the Progression of Glioblastoma through HIF-1α Mediated Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00316.2022
Abstract: Glioblastoma (GBM) is a malignant tumor prone to recurrence and resistant to conventional therapies. GBM cells show high autophagy activity, contributing to its rapid progression. Casein kinase 1 family, such as Casein kinase 1α (CK1α), has shown… read more here.
Keywords: expression; hif; casein kinase; autophagy related ... See more keywords
Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer cell"
DOI: 10.1182/blood-2022-167678
Abstract: Acute myeloid leukemia (AML) is a hematologic malignancy for which several epigenetic regulators have been identified as therapeutic targets. Here we report the development of cereblon-dependent degraders of IKZF2 and casein kinase 1α (CK1α), termed… read more here.
Keywords: ikzf2 ck1; myeloid leukemia; acute myeloid; ikzf2 ... See more keywords
CK1α overexpression correlates with poor survival in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4019-0
Abstract: BackgroundColorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1 isoforms have been reported to be deregulated in several tumor entities… read more here.
Keywords: ck1; poor survival; ck1 overexpression; correlates poor ... See more keywords
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.207316
Abstract: ABSTRACT Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner.… read more here.
Keywords: ck1; fret biosensor; activity; ck1 activity ... See more keywords
FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Reports"
DOI: 10.15252/embr.201847495
Abstract: The concerted action of many protein kinases helps orchestrate the error‐free progression through mitosis of mammalian cells. The roles and regulation of some prominent mitotic kinases, such as cyclin‐dependent kinases, are well established. However, these… read more here.
Keywords: ck1; spindle positioning; proper spindle; fam83d directs ... See more keywords
Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220301115124
Abstract: Casein kinase 1 (CK1) belongs to the serine-threonine kinase family and is expressed in all eukaryotic organisms. At least six human isoforms of CK1 (termed α, γ1-3, δ and ε) have been cloned and characterized.… read more here.
Keywords: promising therapeutic; inhibitors promising; kinase inhibitors; casein kinase ... See more keywords
Cytoplasmic CK1ε Protein Expression Is Correlated With Distant Metastasis and Survival in Patients With Melanoma
Sign Up to like & getrecommendations! Published in 2020 at "In Vivo"
DOI: 10.21873/invivo.12119
Abstract: Background/Aim: Casein kinase 1 epsilon (CK1ε) is a member of the casein kinase 1 family, which includes highly conserved and ubiquitous serine/threonine protein kinases. Recent research has revealed that CK1ε plays an important role in… read more here.
Keywords: protein; protein expression; ck1; ck1 protein ... See more keywords