The CK1ε/SIAH1 axis regulates AXIN1 stability in colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13624
Abstract: Casein kinase 1ε (CK1ε) and axis inhibitor 1 (AXIN1) are crucial components of the β‐catenin destruction complex in canonical Wnt signaling. CK1ε has been shown to interact with AXIN1, but its physiological function and role… read more here.
Keywords: colorectal cancer; crc; siah1 axis; ck1 ... See more keywords
m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406935
Abstract: Colorectal cancer (CRC) is the third most common cancer type and the second highest mortality rate among cancers. However, the mechanisms underlying CRC progression remain to be fully understood. In this work, a recently identified… read more here.
Keywords: colorectal cancer; cancer; yap signaling; wnt yap ... See more keywords
Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.144005
Abstract: Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well… read more here.
Keywords: ck1; physiological functions; stress induced; structure regulation ... See more keywords
The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (kcat/Km) of CK1α.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00891
Abstract: The serine/threonine protein kinase casein kinase 1α (CK1α) functions as a negative regulator of Wnt signaling, phosphorylating β-catenin at serine 45 (P-S45) to initiate its eventual ubiquitin-mediated degradation. We previously showed that the repurposed, FDA-approved… read more here.
Keywords: ck1; wnt; efficiency kcat; pyrvinium enhances ... See more keywords
Structure-Based Development of Isoform-Selective Inhibitors of Casein Kinase 1ε vs Casein Kinase 1δ.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01180
Abstract: Specific inhibition of a single kinase isoform is a challenging task due to the highly conserved nature of ATP-binding sites. Casein kinase 1 (CK1) δ and ε share 97% sequence identity in their catalytic domains.… read more here.
Keywords: isoform selective; casein kinase; ck1; structure ... See more keywords
Structure-Based Optimization of Selective and Brain Penetrant CK1δ Inhibitors for the Treatment of Circadian Disruptions.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00523
Abstract: Neuropsychiatric disorders such as major depressive disorders and schizophrenia are often associated with disruptions to the normal 24 h sleep wake cycle. Casein kinase 1 (CK1δ) is an integral part of the molecular machinery that… read more here.
Keywords: structure based; brain; optimization selective; structure ... See more keywords
Casein kinase I isoforms contribute to platelet activation and thrombogenesis via RIPK3–MLKL signaling
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08868-1
Abstract: Platelets are small, enucleate blood cells having life span of 10-12 days that play fundamental role in hemostasis and thrombosis. Casein Kinase 1 (CK1) is a serine/threonine-specific protein kinase that governs multiple cellular processes including… read more here.
Keywords: biology; activation; ck1; platelet activation ... See more keywords
Autophosphorylation of conserved yeast and human casein kinase 1 isozymes regulates Elongator-dependent tRNA modifications
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf881
Abstract: Abstract Casein kinase 1 (CK1) family members are crucial for ER-Golgi trafficking, calcium signalling, DNA repair, transfer RNA (tRNA) modifications, and circadian rhythmicity. Whether and how substrate interactions and kinase autophosphorylation contribute to CK1 plasticity… read more here.
Keywords: elongator dependent; casein kinase; ck1; kinase ... See more keywords
FRQ-CK1 Interaction Underlies Temperature Compensation of the Neurospora Circadian Clock
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.01425-21
Abstract: Temperature compensation allows clocks to adapt to all seasons by having a relatively constant period length at different physiological temperatures, but the mechanism of temperature compensation is unclear. Stability of clock proteins was previously proposed… read more here.
Keywords: ck1; interaction; temperature compensation; clock ... See more keywords
Casein Kinase 1 Alpha 1 is Involved in the Progression of Glioblastoma through HIF-1α Mediated Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00316.2022
Abstract: Glioblastoma (GBM) is a malignant tumor prone to recurrence and resistant to conventional therapies. GBM cells show high autophagy activity, contributing to its rapid progression. Casein kinase 1 family, such as Casein kinase 1α (CK1α), has shown… read more here.
Keywords: expression; hif; casein kinase; autophagy related ... See more keywords
Abstract 1642: Next trip: a promising CK1α-selective molecular glue degrader in MSS colorectal cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1642
Abstract: Casein kinase 1α (CK1α) is a serine/threonine kinase that plays a critical role in cellular homeostasis. In previous studies, CK1α promotes p53 inactivation by regulating MDM2 and MDMX, and this mechanism may represent a promising… read more here.
Keywords: colorectal cancer; ck1 selective; cancer; next trip ... See more keywords