A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700457
Abstract: Cancer cells express high levels of CK2, and its inhibition leads to apoptosis. CK2 has therefore emerged as a new drug target for cancer therapy. A biligand inhibitor ARC‐772 was constructed by conjugating 4‐(2‐amino‐1,3‐thiazol‐5‐yl)benzoic acid… read more here.
Keywords: cancer; biligand inhibitor; ck2; cancer cells ... See more keywords
Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3228-1
Abstract: CK2 is a pleiotropic, constitutively active protein kinase responsible for the phosphorylation of more than 300 physiological substrates. Typically, this enzyme is found in tetrameric form consisting of two regulatory subunits CK2β and two catalytic… read more here.
Keywords: inhibitory influence; kinase; effect; protein kinase ... See more keywords
Loss of protein kinase 2 subunit alpha 2 (CK2α') effect ram sperm function after freezing and thawing process.
Sign Up to like & getrecommendations! Published in 2017 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2017.01.017
Abstract: Protein kinase 2 subunit alpha 2 (CK2α'), a serine/threonine-selective protein kinase, is associated with sperm apoptosis. However, the presence of CK2α' in ram sperm during the freezing-thawing process has not been previously reported. Thus, this… read more here.
Keywords: ck2; protein kinase; ram sperm;
The casein kinase 2α promotes the occurrence polycystic ovary syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.065
Abstract: Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease characterized by hyperandrogenism, polycystic ovaries, and anovulation. Previous studies have revealed that androgen receptors (ARs) are strongly associated with hyperandrogenism and abnormalities in folliculogenesis in… read more here.
Keywords: kinase promotes; polycystic ovary; ovary syndrome; casein kinase ... See more keywords
Biphasic CK2.1-coated β-glycerophosphate chitosan/LL37-modified layered double hydroxide chitosan composite scaffolds enhance coordinated hyaline cartilage and subchondral bone regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.129531
Abstract: Abstract Articular osteochondral defect is commonly seen after trauma or in patients with degenerative osteoarthritis. Currently, the treatment of osteochondral lesions is still challenging due to the limited healing ability of cartilage as well as… read more here.
Keywords: subchondral bone; ck2; bone regeneration; regeneration ... See more keywords
Intracellular protein kinase CK2 inhibition by ferulic acid-based trimodal nanodevice.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.09.207
Abstract: Protein kinase CK2, a pleiotropic and constitutively active kinase, is strictly involved in different diseases, especially in cancer. Many efforts have been carried out to develop specific CK2 inhibitors and recently, it has been evidenced… read more here.
Keywords: kinase; kinase ck2; trimodal nanodevice; ferulic acid ... See more keywords
Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in biological regulation"
DOI: 10.1016/j.jbior.2016.09.003
Abstract: The IKZF1 gene encodes the Ikaros protein, a zinc finger transcriptional factor that acts as a master regulator of hematopoiesis and a tumor suppressor in leukemia. Impaired activity of Ikaros is associated with the development… read more here.
Keywords: tumor suppressor; kinase; cellular proliferation; ck2 ... See more keywords
Selected flavonoid compounds as promising inhibitors of protein kinase CK2α and CK2α', the catalytic subunits of CK2.
Sign Up to like & getrecommendations! Published in 2017 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2016.12.018
Abstract: CK2 is a ubiquitous protein kinase involved in many cell functions. During the last years it became an interesting target in cancer research. A series of flavonoid compounds was tested as inhibitors of protein kinase… read more here.
Keywords: catalytic subunits; flavonoid compounds; kinase ck2; protein kinase ... See more keywords
DN604: A platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2‐mediated p‐cdc25C subcellular localization in cancer cells
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DOI: 10.1016/j.yexcr.2018.01.031
Abstract: ABSTRACT DN604, a carboplatin analogue with a functional dicarboxylato ligand, was deeply investigated to explore its ability to induce apoptosis as well as its antitumor mechanism of action. Both in vitro and in vivo assays… read more here.
Keywords: apoptosis; dn604; subcellular localization; cancer cells ... See more keywords
Novel CK2-Specific Pt(II) Compound Reverses Cisplatin-Induced Resistance by Inhibiting Cancer Cell Stemness and Suppressing DNA Damage Repair in Non-small Cell Lung Cancer Treatments.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00079
Abstract: Cancer stem cells (CSCs) have a pivotal impact in drug resistance, tumor metastasis, and progression of various cancer entities, including in non-small cell lung cancer (NSCLC). A CK2 inhibitor HY1 was found to show potent… read more here.
Keywords: cisplatin; resistance; non small; cancer ... See more keywords
Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01523
Abstract: CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic cells and plays important roles in a variety of cellular functions, including cell growth, apoptosis, circadian rhythms, DNA damage repair, transcription,… read more here.
Keywords: drug discovery; discovery challenges; ck2 drug; ck2 ... See more keywords