Flavones and flavonols may have clinical potential as CK2 inhibitors in cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.109723
Abstract: The serine-threonine kinase CK2, which targets over 300 cellular proteins, is overexpressed in all cancers, presumably reflecting its ability to promote proliferation, spread, and survival through a wide range of complementary mechanisms. Via an activating… read more here.
Keywords: flavones flavonols; cancer; ck2 inhibitors; inhibitors cancer ... See more keywords
3D-QSAR modeling and molecular docking studies on a series of 2, 4, 5-trisubstituted imidazole derivatives as CK2 inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2014360
Abstract: Abstract Protein case in kinase II alpha subunit (CK2) plays an imperative function in treating cancer disease. Herein, we have performed a three-dimensional quantitative structure activity relationship (3D-QSAR), and molecular docking analysis on a novel… read more here.
Keywords: molecular docking; series trisubstituted; imidazole derivatives; analysis ... See more keywords
Inhibiting CK2 among Promising Therapeutic Strategies for Gliomas and Several Other Neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020331
Abstract: In gliomas, casein kinase 2 (CK2) plays a dominant role in cell survival and tumour invasiveness and is upregulated in many brain tumours. Among CK2 inhibitors, benzimidazole and isothiourea derivatives hold a dominant position. While… read more here.
Keywords: among promising; promising therapeutic; ck2 inhibitors; inhibiting ck2 ... See more keywords