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   Articles with "cko mice" as a keyword



AKT2 Modulates Astrocytic Nicotine Responses In Vivo

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recommendations! Published in 2025 at "Glia"

DOI: 10.1002/glia.70059

Abstract: A greater understanding of the neurobiology of nicotine is needed to reduce or prevent chronic addiction, ameliorate detrimental nicotine withdrawal effects, and improve cessation rates. Nicotine binds and activates two astrocyte‐expressed nicotinic acetylcholine receptors (nAChRs),… read more here.

Keywords: akt2 modulates; cko mice; akt2; nicotine ... See more keywords

Targeted Disruption of NF1 in Osteocytes Increases FGF23 and Osteoid With Osteomalacia‐like Bone Phenotype

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recommendations! Published in 2017 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.3155

Abstract: Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi‐system abnormalities, including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the… read more here.

Keywords: osteomalacia like; like bone; bone phenotype; cko mice ... See more keywords

PQBP1, an intellectual disability causative gene, affects bone development and growth.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.12.097

Abstract: Polyglutamine tract-binding protein 1 (PQBP1), an intellectual disability causative gene, is involved in transcriptional and post-transcriptional regulation of gene expression in animals, and possibly also in plants. In our previous work, reduced brain size, associated… read more here.

Keywords: intellectual disability; cko mice; bone; pqbp1 intellectual ... See more keywords
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Type I IFN signaling in T regulatory cells modulates chemokine production and myeloid derived suppressor cells trafficking during EAE.

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recommendations! Published in 2020 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2020.102525

Abstract: Interferon-β has therapeutic efficacy in Multiple Sclerosis by reducing disease exacerbations and delaying relapses. Previous studies have suggested that the effects of type I IFN in Experimental Autoimmune Encephalomyelitis (EAE) in mice were targeted to… read more here.

Keywords: type ifn; chemokine production; production; cko mice ... See more keywords

Heparan Sulfate Deficiency Leads to Hypertrophic Chondrocytes by Increasing Bone Morphogenetic Protein Signaling.

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recommendations! Published in 2020 at "Osteoarthritis and cartilage"

DOI: 10.1016/j.joca.2020.08.003

Abstract: OBJECTIVE Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis. Previous studies investigating HS in several mouse models of multiple hereditary exostoses have… read more here.

Keywords: hypertrophic chondrocytes; cko mice; mice; ext1 cko ... See more keywords

Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-08914-6

Abstract: NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surprisingly, we… read more here.

Keywords: age; bone; cko mice; osx cre ... See more keywords

Inducible deletion of microRNA activity in kidney mesenchymal cells exacerbates renal fibrosis

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-61560-y

Abstract: MicroRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. However, the physiological functions of these non-coding RNAs in renal interstitial mesenchymal cells remain unclear. To conclusively evaluate the role of miRNAs, we generated conditional knockout… read more here.

Keywords: fibrosis; renal fibrosis; mesenchymal cells; mir ... See more keywords
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#2505 PTEN ablation in osteocytes exacerbates anemia in mice with subtotal nephrectomy

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recommendations! Published in 2024 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfae069.662

Abstract: The identification of novel roles for bone as a principal endocrine organ has grown in recent decades, being now recognized for its contribution to the regulation of numerous systemic functions. In previous studies, we observed… read more here.

Keywords: mice; pten ocy; ocy cko; bone ... See more keywords

Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice.

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recommendations! Published in 2022 at "Schizophrenia bulletin"

DOI: 10.1093/schbul/sbac040

Abstract: OBJECTIVES Despite of strenuous research in the past decades, the etiology of schizophrenia (SCZ) still remains incredibly controversial. Previous genetic analysis has uncovered a close association of Unc-51 like kinase 4 (ULK4), a family member… read more here.

Keywords: cko mice; gsk signaling; signaling pathway; akt gsk ... See more keywords

Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge

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recommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2022.0168

Abstract: P21-activated kinase 1 (Pak1) signalling plays a vital and overall protective role in the heart. However, the phenotypes of Pak1 deficiency in the cardiac atria have not been well explored. In this study, Pak1 cardiac-conditional… read more here.

Keywords: cko mice; activated kinase; p21 activated; mice ... See more keywords

Iron trapping in macrophages reshapes the homeostasis of the haematopoietic system

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recommendations! Published in 2025 at "British Journal of Haematology"

DOI: 10.1111/bjh.20031

Abstract: Iron is required for key physiological processes, like oxygen transport, energy production and cell proliferation. Body iron homeostasis is regulated by the erythroferrone–hepcidin–ferroportin (FPN) axis, which mainly acts on absorptive duodenal cells and macrophages involved… read more here.

Keywords: fpn cko; iron; cko mice; homeostasis ... See more keywords