Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3155
Abstract: Neurofibromatosis type 1 (NF1, OMIM 162200), caused by NF1 gene mutations, exhibits multi‐system abnormalities, including skeletal deformities in humans. Osteocytes play critical roles in controlling bone modeling and remodeling. However, the role of neurofibromin, the…
read more here.
Keywords:
osteomalacia like;
like bone;
bone phenotype;
cko mice ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.12.097
Abstract: Polyglutamine tract-binding protein 1 (PQBP1), an intellectual disability causative gene, is involved in transcriptional and post-transcriptional regulation of gene expression in animals, and possibly also in plants. In our previous work, reduced brain size, associated…
read more here.
Keywords:
intellectual disability;
cko mice;
bone;
pqbp1 intellectual ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
1
Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102525
Abstract: Interferon-β has therapeutic efficacy in Multiple Sclerosis by reducing disease exacerbations and delaying relapses. Previous studies have suggested that the effects of type I IFN in Experimental Autoimmune Encephalomyelitis (EAE) in mice were targeted to…
read more here.
Keywords:
type ifn;
chemokine production;
production;
cko mice ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2020 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2020.08.003
Abstract: OBJECTIVE Exostosin-1 (EXT1) and EXT2 are the major genetic etiologies of multiple hereditary exostoses and are essential for heparan sulfate (HS) biosynthesis. Previous studies investigating HS in several mouse models of multiple hereditary exostoses have…
read more here.
Keywords:
hypertrophic chondrocytes;
cko mice;
mice;
ext1 cko ... See more keywords
Photo from wikipedia
Sign Up to like & get
recommendations!
3
Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08914-6
Abstract: NF-κB has been reported to both promote and inhibit bone formation. To explore its role in osteolineage cells, we conditionally deleted IKKα, an upstream kinase required for non-canonical NF-κB activation, using Osterix (Osx)-Cre. Surprisingly, we…
read more here.
Keywords:
age;
bone;
cko mice;
osx cre ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "Schizophrenia bulletin"
DOI: 10.1093/schbul/sbac040
Abstract: OBJECTIVES Despite of strenuous research in the past decades, the etiology of schizophrenia (SCZ) still remains incredibly controversial. Previous genetic analysis has uncovered a close association of Unc-51 like kinase 4 (ULK4), a family member…
read more here.
Keywords:
cko mice;
gsk signaling;
signaling pathway;
akt gsk ... See more keywords
Sign Up to like & get
recommendations!
2
Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0168
Abstract: P21-activated kinase 1 (Pak1) signalling plays a vital and overall protective role in the heart. However, the phenotypes of Pak1 deficiency in the cardiac atria have not been well explored. In this study, Pak1 cardiac-conditional…
read more here.
Keywords:
cko mice;
activated kinase;
p21 activated;
mice ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2020 at "JCI Insight"
DOI: 10.1172/jci.insight.140229
Abstract: Inosine triphosphate pyrophosphatase (ITPA) hydrolyzes inosine triphosphate (ITP) and other deaminated purine nucleotides to the corresponding nucleoside monophosphates. In humans, ITPA deficiency causes severe encephalopathy with epileptic seizure, microcephaly, and developmental retardation. In this study,…
read more here.
Keywords:
itpa deficiency;
cko mice;
mice;
itpa cko ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155836
Abstract: Peroxisomes are specialized cellular organelles involved in a variety of metabolic processes. In humans, mutations leading to complete loss of peroxisomes cause multiorgan failure (Zellweger’s spectrum disorders, ZSD), including renal impairment. However, the (patho)physiological role…
read more here.
Keywords:
cko mice;
function;
peroxisomes dispensable;
kidney ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190800
Abstract: The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected…
read more here.
Keywords:
mafb;
spermatogenesis;
adult;
cko mice ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2021.815713
Abstract: Developmental dysregulation of dopamine D2 receptors (D2Rs) alters neuronal migration, differentiation, and behavior and contributes to the psychopathology of neurological and psychiatric disorders. The current study is aimed at identifying how cell-specific loss of D2Rs…
read more here.
Keywords:
d2r;
cko mice;
d2r cko;
gaba d2r ... See more keywords