Unexpected new insights into DNA clamp loaders
Sign Up to like & getrecommendations! Published in 2022 at "Bioessays"
DOI: 10.1002/bies.202200154
Abstract: Clamp loaders are pentameric AAA+ assemblies that use ATP to open and close circular DNA sliding clamps around DNA. Clamp loaders show homology in all organisms, from bacteria to human. The eukaryotic PCNA clamp is… read more here.
Keywords: clamp loaders; clamp; dna; dna clamp ... See more keywords
Mechanism of opening a sliding clamp
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx665
Abstract: Abstract Clamp loaders load ring-shaped sliding clamps onto DNA where the clamps serve as processivity factors for DNA polymerases. In the first stage of clamp loading, clamp loaders bind and stabilize clamps in an open… read more here.
Keywords: clamp loader; sliding clamp; mechanism; clamp loaders ... See more keywords
Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.66181
Abstract: Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in… read more here.
Keywords: bonded junction; clamp loaders; clamp; hydrogen bonded ... See more keywords