Evidence of mutations conferring resistance to clarithromycin in wastewater and activated sludge
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DOI: 10.1007/s13205-019-1989-9
Abstract: The occurrence of clarithromycin in wastewater samples and of the activated sludge bacteria possibly resistant to this pharmaceutical was the object of the study. Samples of wastewater or activated sludge were taken from a municipal… read more here.
Keywords: clarithromycin; clarithromycin wastewater; resistance; activated sludge ... See more keywords
The Effects of Clarithromycin on the Pharmacokinetics of Apixaban in Healthy Volunteers: A Single-Sequence Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-019-00348-2
Abstract: BackgroundThis was an open-label, phase I, nonrandomized, single-sequence, crossover study to evaluate the effect of concomitant administration of multiple doses of clarithromycin on the single-dose exposure, safety, and tolerability of apixaban in healthy subjects.MethodsIn total,… read more here.
Keywords: sequence crossover; administration; single sequence; clarithromycin ... See more keywords
The oral administration of clarithromycin prevents the progression and rupture of aortic aneurysm
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2017.12.047
Abstract: Objective: The pathogenesis of aortic aneurysm (AA) is associated with chronic inflammation in the aortic wall with increased levels of matrix metalloproteinases (MMPs). Clarithromycin (CAM) has been reported to suppresses MMP activity. In this study,… read more here.
Keywords: rupture; clarithromycin; mmp; aortic aneurysm ... See more keywords
In vitro performances and cellular uptake of clarithromycin nanocrystals produced by media milling technique
Sign Up to like & getrecommendations! Published in 2018 at "Powder Technology"
DOI: 10.1016/j.powtec.2018.07.036
Abstract: Abstract Nanocrystal technology is one of a promising approach used to improve the solubility of poorly soluble drugs. In this study, media milling technique was used to produce clarithromycin nanocrystals via a bead milling machine.… read more here.
Keywords: clarithromycin; solubility; media milling; clarithromycin nanocrystals ... See more keywords
A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(E)-Oxime with an Established Control of the (Z)-Isomer Impurity
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DOI: 10.1021/acsomega.2c08207
Abstract: Controlling the isomeric impurity in a key raw material is always critical to achieve the corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. Clarithromycin 9-(E)-oxime is the key raw material for the… read more here.
Keywords: clarithromycin; scalable process; clarithromycin oxime; synthesis ... See more keywords
Molecular detection of mutations involved in Helicobacter pylori antibiotic resistance in Algeria
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DOI: 10.1093/jac/dky167
Abstract: Objectives In Algeria, there are limited data regarding the pattern of Helicobacter pylori primary antibiotic resistance. The aim of this study was to evaluate the primary resistance of H. pylori to clarithromycin, ciprofloxacin, tetracycline and… read more here.
Keywords: clarithromycin; ciprofloxacin; resistance; antibiotic resistance ... See more keywords
Role of MIC levels of resistance to clarithromycin and metronidazole in Helicobacter pylori eradication
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DOI: 10.1093/jac/dky469
Abstract: OBJECTIVES Antimicrobial resistance to clarithromycin and metronidazole significantly affects the cure rate of standard therapies for Helicobacter pylori infection. We tested whether different MIC levels of resistance to these antibiotics play a role in therapeutic… read more here.
Keywords: clarithromycin; levels resistance; clarithromycin metronidazole; resistant strains ... See more keywords
Helicobacter pylori-Clarithromycin Resistance in Symptomatic Pediatric Patients in a High Prevalence Country
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DOI: 10.1097/mpg.0000000000001257
Abstract: Introduction: Failure to eradicate Helicobacter pylori despite antibiotic treatment is generally attributed to increasing clarithromycin resistance conferred by point mutations in the 23S-rRNA gene or metronidazole resistance attributed to rdxA gene (HP0954) deletion in patients.… read more here.
Keywords: clarithromycin; clarithromycin resistance; gene; mutation ... See more keywords
A greater effect on clarithromycin resistance of mef(A)‐associated msr(D) than mef(E)‐associated msr(D) in Streptococcus pyogenes
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DOI: 10.1111/1348-0421.12974
Abstract: The mef(A)‐ and its subclass mef(E) systems had long been considered to constitute one of the primary macrolide‐resistant mechanisms in Streptococcus pyogenes. However, we have previously demonstrated that the msr(D) gene located immediately downstream of… read more here.
Keywords: clarithromycin; mef associated; associated msr; streptococcus pyogenes ... See more keywords
High prevalence of Helicobacter pylori clarithromycin resistance mutations among Seattle patients measured by droplet digital PCR
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DOI: 10.1111/hel.12472
Abstract: Treatment of Helicobacter pylori infection is often empiric; however, current guidelines for management of Helicobacter pylori infection advise against the use of standard triple therapy (clarithromycin, amoxicillin, and proton‐pump inhibitor) when clarithromycin resistance exceeds 20%.… read more here.
Keywords: clarithromycin; clarithromycin resistance; helicobacter pylori;
Increasing Helicobacter pylori clarithromycin resistance in Australia over 20 years.
Sign Up to like & getrecommendations! Published in 2021 at "Internal medicine journal"
DOI: 10.1111/imj.15640
Abstract: OBJECTIVES Helicobacter pylori infection is responsible for considerable morbidity and mortality worldwide, and eradication rates are falling in many countries, primarily due to clarithromycin and metronidazole resistance. However, there is a paucity of contemporary Australian… read more here.
Keywords: clarithromycin resistance; clarithromycin; resistance; helicobacter pylori ... See more keywords