A Robust and Scalable Process for the Synthesis of Substantially Pure Clarithromycin 9-(E)-Oxime with an Established Control of the (Z)-Isomer Impurity
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DOI: 10.1021/acsomega.2c08207
Abstract: Controlling the isomeric impurity in a key raw material is always critical to achieve the corresponding pure isomer-free targeted active pharmaceutical ingredient (API) in downstream processing. Clarithromycin 9-(E)-oxime is the key raw material for the… read more here.
Keywords: clarithromycin; scalable process; clarithromycin oxime; synthesis ... See more keywords