Helicobacter pylori-Clarithromycin Resistance in Symptomatic Pediatric Patients in a High Prevalence Country
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DOI: 10.1097/mpg.0000000000001257
Abstract: Introduction: Failure to eradicate Helicobacter pylori despite antibiotic treatment is generally attributed to increasing clarithromycin resistance conferred by point mutations in the 23S-rRNA gene or metronidazole resistance attributed to rdxA gene (HP0954) deletion in patients.… read more here.
Keywords: clarithromycin; clarithromycin resistance; gene; mutation ... See more keywords
High prevalence of Helicobacter pylori clarithromycin resistance mutations among Seattle patients measured by droplet digital PCR
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DOI: 10.1111/hel.12472
Abstract: Treatment of Helicobacter pylori infection is often empiric; however, current guidelines for management of Helicobacter pylori infection advise against the use of standard triple therapy (clarithromycin, amoxicillin, and proton‐pump inhibitor) when clarithromycin resistance exceeds 20%.… read more here.
Keywords: clarithromycin; clarithromycin resistance; helicobacter pylori;
Increasing Helicobacter pylori clarithromycin resistance in Australia over 20 years.
Sign Up to like & getrecommendations! Published in 2021 at "Internal medicine journal"
DOI: 10.1111/imj.15640
Abstract: OBJECTIVES Helicobacter pylori infection is responsible for considerable morbidity and mortality worldwide, and eradication rates are falling in many countries, primarily due to clarithromycin and metronidazole resistance. However, there is a paucity of contemporary Australian… read more here.
Keywords: clarithromycin resistance; clarithromycin; resistance; helicobacter pylori ... See more keywords
A Novel Stool PCR Test for Helicobacter pylori May Predict Clarithromycin Resistance and Eradication of Infection at a High Rate
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00506-17
Abstract: ABSTRACT Clarithromycin-based regimens are commonly used as a first-line therapy for Helicobacter pylori-positive patients; however, resistance to clarithromycin has led to treatment failures. The aim of this study was to evaluate the feasibility of using… read more here.
Keywords: clarithromycin; clarithromycin resistance; resistance; helicobacter pylori ... See more keywords
Detection of Mixed Populations of Clarithromycin-Susceptible and -Resistant Mycobacterium abscessus Strains
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DOI: 10.1128/jcm.01694-21
Abstract: Clarithromycin resistance in Mycobacterium abscessus subsp. abscessus, massiliense, and bolletii occurs through induction of erm(41) or mutations in rrl (23S rRNA) genes. Phenotypic detection of clarithromycin resistance is hindered by the need for extended incubation… read more here.
Keywords: clarithromycin resistance; mixed populations; detection; resistance ... See more keywords
Clinical Evaluation of a Real-Time PCR Assay for Simultaneous Detection of Helicobacter pylori and Genotypic Markers of Clarithromycin Resistance Directly from Stool
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DOI: 10.1128/jcm.03040-20
Abstract: Helicobacter pylori infection is mainly diagnosed noninvasively, with susceptibility testing traditionally requiring endoscopy. Treatment is empirical, with clarithromycin-based triple therapy recommended where resistance rates are below 15%. Rising rates of clarithromycin resistance, resulting in high… read more here.
Keywords: helicobacter pylori; pcr assay; resistance; clarithromycin based ... See more keywords
Efficacy of Phenotype-vs. Genotype-Guided Therapy Based on Clarithromycin Resistance for Helicobacter pylori Infection in Children
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DOI: 10.3389/fped.2022.854519
Abstract: Background Clarithromycin resistance reduces the eradication rate of Helicobacter pylori (H. pylori). Cultures with susceptibility testing and molecular determination of genotypes are recommended to guide-tailored therapy. Methods We retrospectively enrolled patients aged 6 and 18… read more here.
Keywords: clarithromycin resistance; genotype guided; guided therapy; therapy ... See more keywords
Antibiotic Susceptibility and Clarithromycin Resistance Determinants in Helicobacter pylori in the Northeast of Spain: A One-Year Prospective Study
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DOI: 10.3390/antibiotics12020356
Abstract: Helicobacter pylori is one of the most widespread infections, and it is reaching alarming resistance levels worldwide. The recommended first-line empirical treatment differs according to the local rate of clarithromycin resistance. Macrolide resistance is mainly… read more here.
Keywords: clarithromycin resistance; resistance; study; antibiotic susceptibility ... See more keywords
Helicobacter pylori Virulence Factors and Clarithromycin Resistance-Associated Mutations in Mexican Patients
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DOI: 10.3390/pathogens12020234
Abstract: Persistent infection with Helicobacter pylori (H. pylori) is an important factor in gastric diseases. The vacA and cagA virulence factors of H. pylori contribute to the development of these diseases. Triple therapy containing clarithromycin has… read more here.
Keywords: associated mutations; clarithromycin resistance; resistance; virulence factors ... See more keywords