PARP1-TRPM2-PKC cascade distinctly regulates reactive astrogliosis and clasmatodendrosis through NF-κB and AKT pathways in the hippocampus of chronic epilepsy rats
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DOI: 10.1038/s41598-025-22229-2
Abstract: The epileptic hippocampi of rodent models show reactive astrogliosis and autophagic astroglial death (clasmatodendrosis) in the CA1 region, which contributes to spontaneous seizures. Oxidative stress upregulates transient receptor potential melastatin 2 (TRPM2, a non-selective Ca2+… read more here.
Keywords: astrogliosis clasmatodendrosis; phosphorylation; reactive astrogliosis; clasmatodendrosis ... See more keywords
Sp1-Mediated Prdx6 Upregulation Leads to Clasmatodendrosis by Increasing Its aiPLA2 Activity in the CA1 Astrocytes in Chronic Epilepsy Rats
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DOI: 10.3390/antiox11101883
Abstract: Clasmatodendrosis is an autophagic astroglial degeneration (a non-apoptotic (type II) programmed cell death) whose underlying mechanisms are fully understood. Peroxiredoxin-6 (Prdx6), the “non-selenium glutathione peroxidase (NSGPx)”, is the only member of the 1-cysteine peroxiredoxin family.… read more here.
Keywords: chronic epilepsy; clasmatodendrosis; aipla2 activity; epilepsy rats ... See more keywords