A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention
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DOI: 10.1080/19420862.2021.1946918
Abstract: ABSTRACT Passive transfer of broadly neutralizing antibodies is showing promise in the treatment and prevention of HIV-1. One class of antibodies, the VRC01 class, appears especially promising. To improve VRC01-class antibodies, we combined structure-based design… read more here.
Keywords: class antibodies; class; matrix; vrc01 class ... See more keywords
HLA Class II Antibodies at the Time of Kidney Transplantation and Cardiovascular Outcome: A Retrospective Cohort Study
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DOI: 10.1097/tp.0000000000002889
Abstract: Supplemental Digital Content is available in the text. Background. The negative role of HLA class II donor-specific antibody on graft outcome is well recognized. However, the potentially negative cardiovascular effects of preformed HLA class II… read more here.
Keywords: hla class; outcome; class antibodies; transplantation ... See more keywords
Human leukocyte antigen (HLA) class I antibodies and transfusion support in paediatric HLA‐matched haematopoietic cell transplant for sickle cell disease
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DOI: 10.1111/bjh.16298
Abstract: The relevance of donor‐specific human leukocyte antigen (HLA) antibodies in HLA‐mismatched haematopoietic cell transplant (HCT) is known, but the importance of HLA antibodies in HLA‐matched HCT is unclear. We hypothesized that HLA antibodies detected before… read more here.
Keywords: hla matched; class antibodies; hla class; hla ... See more keywords
Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses
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DOI: 10.3389/fimmu.2021.662909
Abstract: Sequence signatures of multidonor broadly neutralizing influenza antibodies can be used to quantify the prevalence of B cells with virus-neutralizing potential to accelerate development of broadly protective vaccine strategies. Antibodies of the same class share… read more here.
Keywords: class antibodies; sequence signature; class; neutralize diverse ... See more keywords