Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
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DOI: 10.1021/acs.jmedchem.1c01806
Abstract: Monoacylglycerol lipase (MAGL) is the enzyme responsible for the metabolism of 2-arachidonoylglycerol in the brain and the hydrolysis of peripheral monoacylglycerols. Many studies demonstrated beneficial effects deriving from MAGL inhibition for neurodegenerative diseases, inflammatory pathologies,… read more here.
Keywords: new class; monoacylglycerol lipase; class; class benzylpiperidine ... See more keywords