Abstract 4078: Tumors with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4078
Abstract: Approximately two hundred mutant BRAF alleles have been identified in human tumors. Physiologic activation of RAF isoforms requires RAS-dependent induction of their dimerization. Activating BRAF mutants cause ERK dependent feedback inhibition of RAS.GTP and are… read more here.
Keywords: braf mutants; class braf; mutants sensitive; braf ... See more keywords
Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant
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DOI: 10.3390/biom12070905
Abstract: The kinome specific co-chaperone, CDC37, is responsible for delivering BRAF to the Hsp90 complex, where it is then translocated to the RAS complex at the plasma membrane for RAS mediated dimerization and subsequent activation. We… read more here.
Keywords: recognition; class braf; braf; cdc37 ... See more keywords