A Unique Class of Cyclases with a Kinase Fold Catalyzes Enethiol-Mediated Macrocyclization of Aminovinyl-Cysteine Motifs in Lanthipeptides
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DOI: 10.1021/acscentsci.5c00569
Abstract: 2-Aminovinyl-cysteine (AviCys) motifs represent a unique class of macrocyclic structures found in many ribosomally synthesized and post-translationally modified peptides (RiPPs). Despite their essential role in bioactivity, their biosynthetic machinery, particularly the cyclases catalyzing Avi(Me)Cys macrocyclization,… read more here.
Keywords: macrocyclization; aminovinyl cysteine; class; class cyclases ... See more keywords